Zika virus vaccines: Challenges and perspectives

Raquel Das Neves Almeida; Trina Racine; Kelly G. Magalhães; Gary P. Kobinger

doi:10.3390/vaccines6030062

Zika virus vaccines: Challenges and perspectives

Raquel Das Neves Almeida, Trina Racine, Kelly G. Magalhães, Gary P. Kobinger

Research output: Contribution to journal › Review article › peer-review

Abstract

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.

Original language	English (US)
Article number	62
Journal	Vaccines
Volume	6
Issue number	3
DOIs	https://doi.org/10.3390/vaccines6030062
State	Published - Sep 13 2018
Externally published	Yes

Keywords

Animal models
Challenge
Clinical trials
Flaviviruses
Immune responses
Immunopathology
Vaccines
Zika virus

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

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10.3390/vaccines6030062

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title = "Zika virus vaccines: Challenges and perspectives",

abstract = "Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.",

keywords = "Animal models, Challenge, Clinical trials, Flaviviruses, Immune responses, Immunopathology, Vaccines, Zika virus",

author = "Almeida, {Raquel Das Neves} and Trina Racine and Magalh{\~a}es, {Kelly G.} and Kobinger, {Gary P.}",

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AU - Almeida, Raquel Das Neves

AU - Racine, Trina

AU - Magalhães, Kelly G.

AU - Kobinger, Gary P.

PY - 2018/9/13

Y1 - 2018/9/13

N2 - Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.

AB - Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.

KW - Animal models

KW - Challenge

KW - Clinical trials

KW - Flaviviruses

KW - Immune responses

KW - Immunopathology

KW - Vaccines

KW - Zika virus

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JO - Vaccines

JF - Vaccines

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ER -

Zika virus vaccines: Challenges and perspectives

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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