Zika Virus Vaccine: Progress and Challenges

Chao Shan, Xuping Xie, Pei Yong Shi

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


The explosive emergence of Zika virus has inspired a global effort to develop vaccines. Zika virus, which is a flavivirus primarily transmitted by mosquitoes, can cause devastating congenital syndrome in fetuses of pregnant women, including microcephaly, craniofacial disproportion, spasticity, ocular abnormalities, and miscarriage. In adults, Zika infection has been linked to the autoimmune disorder Guillain-Barré syndrome. Thus, despite the current waning in newly reported Zika infections, an efficacious vaccine is urgently needed to help limit the emergence of another detrimental epidemic. Here we summarize the current status of the Zika vaccine pipeline and highlight the challenges for clinical efficacy trials. Shan et al. review the current status of the Zika virus vaccine pipeline, highlight the challenges for efficacy trial in humans, underline the knowledge gaps required for clinical development, and provide potential solutions to overcome the barriers toward licensure.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalCell Host and Microbe
Issue number1
StatePublished - Jul 11 2018

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


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