Yellow fever outbreak in eastern senegal, 2020–2021

Moussa Moïse Diagne, Marie Henriette Dior Ndione, Alioune Gaye, Mamadou Aliou Barry, Diawo Diallo, Amadou Diallo, Lusajo L. Mwakibete, Mamadou Diop, El Hadji Ndiaye, Vida Ahyong, Babacar Diouf, Moufid Mhamadi, Cheikh Tidiane Diagne, Fodé Danfakha, Boly Diop, Oumar Faye, Cheikh Loucoubar, Gamou Fall, Cristina M. Tato, Amadou Alpha SallScott C. Weaver, Mawlouth Diallo, Ousmane Faye

Research output: Contribution to journalArticlepeer-review


Yellow fever virus remains a major threat in low resource countries in South America and Africa despite the existence of an effective vaccine. In Senegal and particularly in the eastern part of the country, periodic sylvatic circulation has been demonstrated with varying degrees of impact on populations in perpetual renewal. We report an outbreak that occurred from October 2020 to February 2021 in eastern Senegal, notified and managed through the synergistic effort yellow fever national surveillance implemented by the Senegalese Ministry of Health in collaboration with the World Health Organization, the countrywide 4S network set up by the Ministry of Health, the Institut Pasteur de Dakar, and the surveillance of arboviruses and hemorrhagic fever viruses in human and vector populations implemented since mid 2020 in eastern Senegal. Virological analyses highlighted the implication of sylvatic mosquito species in virus transmission. Genomic analysis showed a close relationship between the circulating strain in eastern Senegal, 2020, and another one from the West African lineage previously detected and sequenced two years ago from an unvaccinated Dutch traveler who visited the Gambia and Senegal before developing signs after returning to Europe. Moreover, genome analysis identified a 6-nucleotide deletion in the variable domain of the 3 UTR with potential impact on the biology of the viral strain that merits further investigations. Integrated surveillance of yellow fever virus but also of other arboviruses of public health interest is crucial in an ecosystem such as eastern Senegal.

Original languageEnglish (US)
Article number1475
Issue number8
StatePublished - Aug 2021
Externally publishedYes


  • 3 UTR
  • Arbovirus
  • Eastern senegal
  • Genotype
  • Kedougou
  • Lineage
  • Next generation sequencing
  • Sylvatic lifecycle
  • Virus isolation
  • Yellow fever virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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