Wound healing efficacy of Cannabis sativa L. essential oil in a mouse incisional wound model: A possible link with stress and anxiety

Sanae El Ghacham, Ismail El Bakali, Mohamed Amine Zarouki, Youssef Aoulad El Hadj Ali, Rachid Ismaili, Amina El Ayadi, Badredine Souhail, Lahcen Tamegart, Abdelmonaim Azzouz

Research output: Contribution to journalArticlepeer-review

Abstract

Cannabis Sativa L. (Cannabaceae) exerts biological effects through its bioactive compounds. Cannabis Sativa L. essential oil (CSEO) is known to have antibacterial properties that can accelerate wound healing. The present study aimed to evaluate the wound healing efficacy of freshly extracted essential oils from Cannabis Sativa L. hydrodistillated from the leaves of the plant. CSEO was analyzed by gas chromatography-mass spectrometry. Neurobehavioral, histological, and biochemical analyses were performed to examine the effects of CSEO application in an incisional wound model. CSEO demonstrated anti-inflammatory activity by reducing neutrophil levels in blood and skin tissue. CSEO acts by accelerating re-epithelialization and granulation tissue formation. Furthermore, CSEO restored incision-induced neurobehavioral changes by reducing cortisol levels. Increased cortisol levels are associated with inhibition of the healing process, anxiolytic effects, and increased vertical locomotor activity in treated animals. The effect of CSEO in the healing process makes it worthy of recommendation as a therapeutic agent for the treatment of skin wounds.

Original languageEnglish (US)
Pages (from-to)488-496
Number of pages9
JournalSouth African Journal of Botany
Volume163
DOIs
StatePublished - Dec 2023
Externally publishedYes

Keywords

  • Anti-inflammatory effect
  • Cannabis sativa essential oil
  • Mouse incisional wound model
  • Neurobehavioral effect
  • Stress and anxiety
  • Wound healing

ASJC Scopus subject areas

  • Plant Science

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