TY - JOUR
T1 - Wound healing efficacy of Cannabis sativa L. essential oil in a mouse incisional wound model
T2 - A possible link with stress and anxiety
AU - Ghacham, Sanae El
AU - Bakali, Ismail El
AU - Zarouki, Mohamed Amine
AU - Ali, Youssef Aoulad El Hadj
AU - Ismaili, Rachid
AU - Ayadi, Amina El
AU - Souhail, Badredine
AU - Tamegart, Lahcen
AU - Azzouz, Abdelmonaim
N1 - Publisher Copyright:
© 2023 SAAB
PY - 2023/12
Y1 - 2023/12
N2 - Cannabis Sativa L. (Cannabaceae) exerts biological effects through its bioactive compounds. Cannabis Sativa L. essential oil (CSEO) is known to have antibacterial properties that can accelerate wound healing. The present study aimed to evaluate the wound healing efficacy of freshly extracted essential oils from Cannabis Sativa L. hydrodistillated from the leaves of the plant. CSEO was analyzed by gas chromatography-mass spectrometry. Neurobehavioral, histological, and biochemical analyses were performed to examine the effects of CSEO application in an incisional wound model. CSEO demonstrated anti-inflammatory activity by reducing neutrophil levels in blood and skin tissue. CSEO acts by accelerating re-epithelialization and granulation tissue formation. Furthermore, CSEO restored incision-induced neurobehavioral changes by reducing cortisol levels. Increased cortisol levels are associated with inhibition of the healing process, anxiolytic effects, and increased vertical locomotor activity in treated animals. The effect of CSEO in the healing process makes it worthy of recommendation as a therapeutic agent for the treatment of skin wounds.
AB - Cannabis Sativa L. (Cannabaceae) exerts biological effects through its bioactive compounds. Cannabis Sativa L. essential oil (CSEO) is known to have antibacterial properties that can accelerate wound healing. The present study aimed to evaluate the wound healing efficacy of freshly extracted essential oils from Cannabis Sativa L. hydrodistillated from the leaves of the plant. CSEO was analyzed by gas chromatography-mass spectrometry. Neurobehavioral, histological, and biochemical analyses were performed to examine the effects of CSEO application in an incisional wound model. CSEO demonstrated anti-inflammatory activity by reducing neutrophil levels in blood and skin tissue. CSEO acts by accelerating re-epithelialization and granulation tissue formation. Furthermore, CSEO restored incision-induced neurobehavioral changes by reducing cortisol levels. Increased cortisol levels are associated with inhibition of the healing process, anxiolytic effects, and increased vertical locomotor activity in treated animals. The effect of CSEO in the healing process makes it worthy of recommendation as a therapeutic agent for the treatment of skin wounds.
KW - Anti-inflammatory effect
KW - Cannabis sativa essential oil
KW - Mouse incisional wound model
KW - Neurobehavioral effect
KW - Stress and anxiety
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85176366100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85176366100&partnerID=8YFLogxK
U2 - 10.1016/j.sajb.2023.11.005
DO - 10.1016/j.sajb.2023.11.005
M3 - Article
AN - SCOPUS:85176366100
SN - 0254-6299
VL - 163
SP - 488
EP - 496
JO - South African Journal of Botany
JF - South African Journal of Botany
ER -