TY - JOUR
T1 - West Nile virus infection in the golden hamster (Mesocricetus auratus)
T2 - A model for west Nile encephalitis
AU - Xiao, Shu Yuan
AU - Guzman, Hilda
AU - Zhang, Hui
AU - Travassos Da Rosa, Amelia P.A.
AU - Tesh, Robert B.
PY - 2001
Y1 - 2001
N2 - This report describes a new hamster model for West Nile (WN) virus encephalitis. Following intraperitoneal inoculation of a New York isolate of WN virus, hamsters had moderate viremia of 5 to 6 days in duration, followed by the development of humoral antibodies. Encephalitic symptoms began 6 days after infection; about half the animals died between the seventh and 14th days. The appearance of viral antigen in the brain and neuronal degeneration also began on the sixth day. WN virus was cultured from the brains of convalescent hamsters up to 53 days after initial infection, suggesting that persistent virus infection occurs. Hamsters offer an inexpensive model for studying the pathogenesis and treatment of WN virus encephalitis.
AB - This report describes a new hamster model for West Nile (WN) virus encephalitis. Following intraperitoneal inoculation of a New York isolate of WN virus, hamsters had moderate viremia of 5 to 6 days in duration, followed by the development of humoral antibodies. Encephalitic symptoms began 6 days after infection; about half the animals died between the seventh and 14th days. The appearance of viral antigen in the brain and neuronal degeneration also began on the sixth day. WN virus was cultured from the brains of convalescent hamsters up to 53 days after initial infection, suggesting that persistent virus infection occurs. Hamsters offer an inexpensive model for studying the pathogenesis and treatment of WN virus encephalitis.
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U2 - 10.3201/eid0704.017420
DO - 10.3201/eid0704.017420
M3 - Article
C2 - 11585537
AN - SCOPUS:0034847892
SN - 1080-6040
VL - 7
SP - 714
EP - 721
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 4
ER -