West Nile virus envelope protein role in diagnosis and immunity

Tian Wang; John F. Anderson; Louis A. Magnarelli; Sandra Bushmich; Susan Wong; Raymond A. Koski; Erol Fikrig

doi:10.1111/j.1749-6632.2001.tb02708.x

West Nile virus envelope protein role in diagnosis and immunity

Tian Wang, John F. Anderson, Louis A. Magnarelli, Sandra Bushmich, Susan Wong, Raymond A. Koski, Erol Fikrig

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.

Original language	English (US)
Pages (from-to)	325-327
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	951
DOIs	https://doi.org/10.1111/j.1749-6632.2001.tb02708.x
State	Published - 2001
Externally published	Yes

Keywords

E protein
Serologic tests
West Nile virus

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1111/j.1749-6632.2001.tb02708.x

Cite this

@article{7f058c05784f4f6595a2982c65f8558f,

title = "West Nile virus envelope protein role in diagnosis and immunity",

abstract = "The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.",

keywords = "E protein, Serologic tests, West Nile virus",

author = "Tian Wang and Anderson, {John F.} and Magnarelli, {Louis A.} and Sandra Bushmich and Susan Wong and Koski, {Raymond A.} and Erol Fikrig",

year = "2001",

doi = "10.1111/j.1749-6632.2001.tb02708.x",

language = "English (US)",

volume = "951",

pages = "325--327",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - West Nile virus envelope protein role in diagnosis and immunity

AU - Wang, Tian

AU - Anderson, John F.

AU - Magnarelli, Louis A.

AU - Bushmich, Sandra

AU - Wong, Susan

AU - Koski, Raymond A.

AU - Fikrig, Erol

PY - 2001

Y1 - 2001

N2 - The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.

AB - The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.

KW - E protein

KW - Serologic tests

KW - West Nile virus

UR - http://www.scopus.com/inward/record.url?scp=0035687089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035687089&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2001.tb02708.x

DO - 10.1111/j.1749-6632.2001.tb02708.x

M3 - Article

C2 - 11797789

AN - SCOPUS:0035687089

SN - 0077-8923

VL - 951

SP - 325

EP - 327

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

West Nile virus envelope protein role in diagnosis and immunity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this