West Nile virus envelope protein role in diagnosis and immunity

Tian Wang, John F. Anderson, Louis A. Magnarelli, Sandra Bushmich, Susan Wong, Raymond A. Koski, Erol Fikrig

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.

Original languageEnglish (US)
Pages (from-to)325-327
Number of pages3
JournalAnnals of the New York Academy of Sciences
StatePublished - 2001
Externally publishedYes


  • E protein
  • Serologic tests
  • West Nile virus

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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