Abstract
Object. Many authors have concluded that the Chiari malformation Type I (CM-I) is due to a smaller than normal posterior cranial fossa. In order to establish this smaller geometry as the cause of hindbrain herniation in a family, the authors of this paper performed volumetric analysis in a family found to have this malformation documented in 4 generations. Methods. Members from this family found to have a CM-I by imaging underwent volumetric analysis of their posterior cranial fossa using the Cavalieri method. Results. No member of this family found to have CM-I on preoperative imaging had a posterior fossa that was significantly smaller than that of age-matched controls. Conclusions. The results of this study demonstrate that not all patients with a CM-I will have a reduced posterior cranial fossa volume. Although the mechanism for the development of hindbrain herniation in this cohort is unknown, this manifestation can be seen in multiple generations of a familial aggregation with normal posterior fossa capacity.
Original language | English (US) |
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Pages (from-to) | 21-24 |
Number of pages | 4 |
Journal | Journal of Neurosurgery: Pediatrics |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2008 |
Externally published | Yes |
Keywords
- Chiari malformation Type I
- Familial condition
- Hindbrain herniation
- Pediatric neurosurgery
- Posterior fossa
- Volumetric measurement
ASJC Scopus subject areas
- Surgery
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology