Vitreoretinal disorders in anterior megalophthalmos

Hamid Ahmadieh, Touka Banaee, Mohammad Ali Javadi, Mohammad Reza Jafarinasab, Shahin Yazdani, Hamid Sajjadi

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose: To describe vitreoretinal abnormalities in patients with anterior megalophthalmos (AM) and to report the results of vitreoretinal surgery in these cases. Methods: In a retrospective, noncomparative case series, a diagnosis of AM was made according to the following criteria: megalocornea, iris hypoplasia, lens subluxation, cataract formation at an early age, and absence of congenital glaucoma. Vitreous biomicroscopy and funduscopy were performed in all patients. Patient records were also reviewed. Results: Twenty-four patients with AM (12 male, 12 female), aged 4 months to 64 years, were included in this study. Funduscopy was possible in 46 eyes. Vitreous degeneration was the most common abnormal posterior segment finding, present in 34 eyes (73.9%). Nine eyes (19.5%) had optically empty vitreous with strands. Lattice degeneration was seen in five eyes (10.8%). Spontaneous vitreous hemorrhage occurred in three eyes, and peripheral retinal neovascularization was detected in two. Retinal detachment occurred in 18 eyes (37.5%); retinal breaks were detected in eight of these before surgery. Thirteen eyes underwent a total of 18 procedures. Retinal reattachment was finally achieved in 12 of the 13 eyes. Conclusions: Anterior megalophthalmic eyes seem to be affected by a type of vitreoretinopathy predisposing to retinal detachment. Current vitreoretinal surgical techniques usually achieve good anatomic results in these cases.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalJapanese Journal of Ophthalmology
Issue number6
StatePublished - Nov 2006
Externally publishedYes


  • Anterior megalophthalmos
  • Retinal detachment
  • Vitreoretinal degeneration

ASJC Scopus subject areas

  • Ophthalmology


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