TY - JOUR
T1 - Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children
AU - Long, Kurt Z.
AU - García, Coralith
AU - Santos, Jose I.
AU - Rosado, Jorge L.
AU - Hertzmark, Ellen
AU - DuPont, Herbert L.
AU - Ko, Gwang Pyo
N1 - Funding Information:
Received 17 January 2007; accepted 14 March 2007; electronically published 22 August 2007. Potential conflicts of interest: none reported. Presented in part: Experimental Biology 2006, San Francisco, 2–6 April 2006 (abstract 399). Financial support: Instituto de Nutrición Danone, CONACYT (National Council of Science and Technology of Mexico); National Institutes of Health (grant K01 DK06142-02); University of Texas Health Science Center (unrestricted grant); Korea Research Foundation (grant E00080 to GP.K.). a Present affiliation: Division of International and Indigenous Health, School of Population Health, University of Queensland, Brisbane, Australia. Reprints or correspondence: Dr. Kurt Z. Long, Div. of International and Indigenous Health, School of Population Health, University of Queensland, Herston Rd., Herston, Brisbane, Queensland 4006 Australia ([email protected]).
PY - 2007
Y1 - 2007
N2 - Background. The effect of vitamin A supplementation on viral gastrointestinal infections among young children living in developing countries remains unclear. Methods. The effect of vitamin A supplementation on norovirus (NoV) infection among 127 Mexican children 5-15 months of age was studied in a randomized, placebo-controlled trial during June-August 1998. Stool samples collected every 2 weeks and after diarrheal episodes were screened for NoV and characterized at the genogroup level (GI and GII). Results. Of the stool samples collected, 29.9% were positive for NoV, and NoV GI and NoV GII were found in 55.4% and 46.4% of the positive samples, respectively. Vitamin A supplementation reduced the prevalence of NoV GII infections (rate ratio [RR], 0.60 [95% confidence interval {CI}, 0.20-0.82]), increased the length of both NoV GI and GII shedding, and decreased the prevalence of NoV-associated diarrhea (RR, 0.51 [95% CI, 0.26-0.97]). Conclusions. These findings suggest that NoV is an important cause of pediatric diarrhea in this study population and that vitamin A supplementation has divergent effects on specific outcomes of NoV infection.
AB - Background. The effect of vitamin A supplementation on viral gastrointestinal infections among young children living in developing countries remains unclear. Methods. The effect of vitamin A supplementation on norovirus (NoV) infection among 127 Mexican children 5-15 months of age was studied in a randomized, placebo-controlled trial during June-August 1998. Stool samples collected every 2 weeks and after diarrheal episodes were screened for NoV and characterized at the genogroup level (GI and GII). Results. Of the stool samples collected, 29.9% were positive for NoV, and NoV GI and NoV GII were found in 55.4% and 46.4% of the positive samples, respectively. Vitamin A supplementation reduced the prevalence of NoV GII infections (rate ratio [RR], 0.60 [95% confidence interval {CI}, 0.20-0.82]), increased the length of both NoV GI and GII shedding, and decreased the prevalence of NoV-associated diarrhea (RR, 0.51 [95% CI, 0.26-0.97]). Conclusions. These findings suggest that NoV is an important cause of pediatric diarrhea in this study population and that vitamin A supplementation has divergent effects on specific outcomes of NoV infection.
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U2 - 10.1086/521195
DO - 10.1086/521195
M3 - Article
C2 - 17763317
AN - SCOPUS:35348866116
SN - 0022-1899
VL - 196
SP - 978
EP - 985
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -