Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis

Eric M. Smith, Walter J. Meyer, J. Edwin Blalock

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201 Scopus citations


Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced and differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.

Original languageEnglish (US)
Pages (from-to)1311-1312
Number of pages2
Issue number4579
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

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