Virulence determinants of West Nile virus: How can these be used for vaccine design?

Jaclyn A. Kaiser; Tian Wang; Alan D.T. Barrett

doi:10.2217/fvl-2016-0141

Virulence determinants of West Nile virus: How can these be used for vaccine design?

Jaclyn A. Kaiser, Tian Wang, Alan D.T. Barrett

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

West Nile virus (WNV), a neurotropic mosquito-borne flavivirus, has become endemic in the USA and parts of Europe since 1999. There is no licensed WNV vaccine for humans. Considering the robust immunity from immunization with live, attenuated vaccines, a live WNV vaccine is an ideal platform for disease control. Animal and mosquito studies have identified a number of candidate attenuating mutations, including the structural proteins premembrane/membrane and envelope, and the nonstructural proteins NS1, NS2A, NS3, NS4A, NS4B and NS5, and the 3′ UTR. Many of the mutations that have been examined attenuate WNV using different mechanisms, thus providing a greater understanding of WNV virulence while also identifying specific mutations as candidates to include in a WNV live vaccine.

Original language	English (US)
Pages (from-to)	283-295
Number of pages	13
Journal	Future Virology
Volume	12
Issue number	5
DOIs	https://doi.org/10.2217/fvl-2016-0141
State	Published - May 2017

Keywords

West Nile virus
attenuation
flavivirus
live attenuated vaccine
virulence

ASJC Scopus subject areas

Virology

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10.2217/fvl-2016-0141

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title = "Virulence determinants of West Nile virus: How can these be used for vaccine design?",

abstract = "West Nile virus (WNV), a neurotropic mosquito-borne flavivirus, has become endemic in the USA and parts of Europe since 1999. There is no licensed WNV vaccine for humans. Considering the robust immunity from immunization with live, attenuated vaccines, a live WNV vaccine is an ideal platform for disease control. Animal and mosquito studies have identified a number of candidate attenuating mutations, including the structural proteins premembrane/membrane and envelope, and the nonstructural proteins NS1, NS2A, NS3, NS4A, NS4B and NS5, and the 3′ UTR. Many of the mutations that have been examined attenuate WNV using different mechanisms, thus providing a greater understanding of WNV virulence while also identifying specific mutations as candidates to include in a WNV live vaccine.",

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T2 - How can these be used for vaccine design?

AU - Kaiser, Jaclyn A.

AU - Wang, Tian

AU - Barrett, Alan D.T.

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N2 - West Nile virus (WNV), a neurotropic mosquito-borne flavivirus, has become endemic in the USA and parts of Europe since 1999. There is no licensed WNV vaccine for humans. Considering the robust immunity from immunization with live, attenuated vaccines, a live WNV vaccine is an ideal platform for disease control. Animal and mosquito studies have identified a number of candidate attenuating mutations, including the structural proteins premembrane/membrane and envelope, and the nonstructural proteins NS1, NS2A, NS3, NS4A, NS4B and NS5, and the 3′ UTR. Many of the mutations that have been examined attenuate WNV using different mechanisms, thus providing a greater understanding of WNV virulence while also identifying specific mutations as candidates to include in a WNV live vaccine.

AB - West Nile virus (WNV), a neurotropic mosquito-borne flavivirus, has become endemic in the USA and parts of Europe since 1999. There is no licensed WNV vaccine for humans. Considering the robust immunity from immunization with live, attenuated vaccines, a live WNV vaccine is an ideal platform for disease control. Animal and mosquito studies have identified a number of candidate attenuating mutations, including the structural proteins premembrane/membrane and envelope, and the nonstructural proteins NS1, NS2A, NS3, NS4A, NS4B and NS5, and the 3′ UTR. Many of the mutations that have been examined attenuate WNV using different mechanisms, thus providing a greater understanding of WNV virulence while also identifying specific mutations as candidates to include in a WNV live vaccine.

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KW - attenuation

KW - flavivirus

KW - live attenuated vaccine

KW - virulence

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Virulence determinants of West Nile virus: How can these be used for vaccine design?

Abstract

Keywords

ASJC Scopus subject areas

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