Viral kinetics of primary dengue virus infection in non-human primates: A systematic review and individual pooled analysis

Benjamin M. Althouse; Anna P. Durbin; Kathryn A. Hanley; Scott B. Halstead; Scott C. Weaver; Derek A.T. Cummings

doi:10.1016/j.virol.2014.01.015

Viral kinetics of primary dengue virus infection in non-human primates: A systematic review and individual pooled analysis

Benjamin M. Althouse, Anna P. Durbin, Kathryn A. Hanley, Scott B. Halstead, Scott C. Weaver, Derek A.T. Cummings

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Viremia kinetics directly influence the clinical course and transmission dynamics of DENV, but many aspects of viral dynamics remain unknown. Non-human primates (NHP) have been used as a model system for DENV infection for decades. Here, we identify papers with experimentally-infected NHP and estimate the time to- and duration of viremia as well as estimate associations between these and serotype, inoculating dose, viremia assay, and species of NHP. We estimate the time to viremia in rhesus macaques to range from 2.63 to 3.32. days for DENV-2 and -1 and the duration to range from 3.13 to 5.13. days for DENV-4 and -2. We find no differences between non-human primates for time to viremia or duration, and a significant negative relationship between inoculating dose and duration of viremia. These results aid in understanding the transmission dynamics of sylvatic DENV non-human primates, an issue of growing importance as dengue vaccines become available.

Original language	English (US)
Pages (from-to)	237-246
Number of pages	10
Journal	Virology
Volume	452-453
DOIs	https://doi.org/10.1016/j.virol.2014.01.015
State	Published - Mar 2014

Keywords

Dengue virus
Non-human primates
Sylvatic dengue
Viral kinetics
Within-host dynamics

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2014.01.015

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@article{8727e1241e634c79bee075a08315b2e5,

title = "Viral kinetics of primary dengue virus infection in non-human primates: A systematic review and individual pooled analysis",

abstract = "Viremia kinetics directly influence the clinical course and transmission dynamics of DENV, but many aspects of viral dynamics remain unknown. Non-human primates (NHP) have been used as a model system for DENV infection for decades. Here, we identify papers with experimentally-infected NHP and estimate the time to- and duration of viremia as well as estimate associations between these and serotype, inoculating dose, viremia assay, and species of NHP. We estimate the time to viremia in rhesus macaques to range from 2.63 to 3.32. days for DENV-2 and -1 and the duration to range from 3.13 to 5.13. days for DENV-4 and -2. We find no differences between non-human primates for time to viremia or duration, and a significant negative relationship between inoculating dose and duration of viremia. These results aid in understanding the transmission dynamics of sylvatic DENV non-human primates, an issue of growing importance as dengue vaccines become available.",

keywords = "Dengue virus, Non-human primates, Sylvatic dengue, Viral kinetics, Within-host dynamics",

author = "Althouse, {Benjamin M.} and Durbin, {Anna P.} and Hanley, {Kathryn A.} and Halstead, {Scott B.} and Weaver, {Scott C.} and Cummings, {Derek A.T.}",

note = "Funding Information: The authors wish to thank Drs. A. Pletnev, A. Goncalvez, R. Purcell and S. Whitehead for kindly providing data, and Josh Pascual for reviewing abstracts. This work was funded by NIH Grant no. AI069145 (PI: SCW, KH, DATC) as well as US NIH National Institute of General Medical Sciences Models of Infectious Disease Agent Study (MIDAS) Grant no. 1U54GM088491-0109 (DATC). BMA acknowledges an NSF Graduate Research Fellowship (Grant no. DGE-0707427 ), and the Omidyar Postdoctoral Fellowship program . DATC holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund. ",

year = "2014",

month = mar,

doi = "10.1016/j.virol.2014.01.015",

language = "English (US)",

volume = "452-453",

pages = "237--246",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

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T1 - Viral kinetics of primary dengue virus infection in non-human primates

T2 - A systematic review and individual pooled analysis

AU - Althouse, Benjamin M.

AU - Durbin, Anna P.

AU - Hanley, Kathryn A.

AU - Halstead, Scott B.

AU - Weaver, Scott C.

AU - Cummings, Derek A.T.

N1 - Funding Information: The authors wish to thank Drs. A. Pletnev, A. Goncalvez, R. Purcell and S. Whitehead for kindly providing data, and Josh Pascual for reviewing abstracts. This work was funded by NIH Grant no. AI069145 (PI: SCW, KH, DATC) as well as US NIH National Institute of General Medical Sciences Models of Infectious Disease Agent Study (MIDAS) Grant no. 1U54GM088491-0109 (DATC). BMA acknowledges an NSF Graduate Research Fellowship (Grant no. DGE-0707427 ), and the Omidyar Postdoctoral Fellowship program . DATC holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund.

PY - 2014/3

Y1 - 2014/3

N2 - Viremia kinetics directly influence the clinical course and transmission dynamics of DENV, but many aspects of viral dynamics remain unknown. Non-human primates (NHP) have been used as a model system for DENV infection for decades. Here, we identify papers with experimentally-infected NHP and estimate the time to- and duration of viremia as well as estimate associations between these and serotype, inoculating dose, viremia assay, and species of NHP. We estimate the time to viremia in rhesus macaques to range from 2.63 to 3.32. days for DENV-2 and -1 and the duration to range from 3.13 to 5.13. days for DENV-4 and -2. We find no differences between non-human primates for time to viremia or duration, and a significant negative relationship between inoculating dose and duration of viremia. These results aid in understanding the transmission dynamics of sylvatic DENV non-human primates, an issue of growing importance as dengue vaccines become available.

AB - Viremia kinetics directly influence the clinical course and transmission dynamics of DENV, but many aspects of viral dynamics remain unknown. Non-human primates (NHP) have been used as a model system for DENV infection for decades. Here, we identify papers with experimentally-infected NHP and estimate the time to- and duration of viremia as well as estimate associations between these and serotype, inoculating dose, viremia assay, and species of NHP. We estimate the time to viremia in rhesus macaques to range from 2.63 to 3.32. days for DENV-2 and -1 and the duration to range from 3.13 to 5.13. days for DENV-4 and -2. We find no differences between non-human primates for time to viremia or duration, and a significant negative relationship between inoculating dose and duration of viremia. These results aid in understanding the transmission dynamics of sylvatic DENV non-human primates, an issue of growing importance as dengue vaccines become available.

KW - Dengue virus

KW - Non-human primates

KW - Sylvatic dengue

KW - Viral kinetics

KW - Within-host dynamics

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JO - Virology

JF - Virology

ER -

Viral kinetics of primary dengue virus infection in non-human primates: A systematic review and individual pooled analysis

Abstract

Keywords

ASJC Scopus subject areas

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