Ventilation practices in burn patients - an international prospective observational cohort study

Marcus J. Schultz, Janneke Horn, Markus W. Hollmann, Benedikt Preckel, Gerie J. Glas, Kirsten Colpaert, Manu Malbrain, Ary Serpa Neto, Karim Asehnoune, Marcello Gamma De Abreu, Ignacio Martin-Loeches, Paolo Pelosi, Folke Sjöberg, Jan M. Binnekade, Berry Cleffken, Nicole P. Juffermans, Paul Knape, Bert G. Loef, David P. Mackie, Perenlei EnkhbaatarNadia Depetris, Anders Perner, Eva Herrero, Lucia Cachafeiro, Marc Jeschke, Jeffrey Lipman, Matthieu Legrand, Johannes Horter, Athina Lavrentieva, Gerie Glas, Alex Kazemi, Anne Berit Guttormsen, Frederik Huss, Mark Kol, Helen Wong, Therese Starr, Luc De Crop, Wilson De Oliveira Filho, João Manoel Silva Junior, Cintia M.C. Grion, Marc G. Jeschke, Marjorie Burnett, Frederik Mondrup, Francois Ravat, Mathieu Fontaine, Karim Asehoune, Renan Le Floch, Mathieu Jeanne, Morgane Bacus, Maïté Chaussard, Marcus Lehnhardt, Bassem Daniel Mikhail, Jochen Gille, Aidan Sharkey, Nicole Trommel, Auke C. Reidinga, Nadine Vieleers, Anna Tilsley, Henning Onarheim, Maria Teresa Bouza, Alexander Agrifoglio, Filip Fredén, Tina Palmieri, Lynda E. Painting

Research output: Contribution to journalArticlepeer-review


Background: It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28). Methods: This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation. Low tidal volume (VT) was defined as VT ≤ 8 mL/kg predicted body weight (PBW). Levels of positive end-expiratory pressure (PEEP) and maximum airway pressures were collected. The association between VT and VFD-28 was analyzed using a competing risk model. Ventilation settings were presented for all patients, focusing on the first day of ventilation. We also compared ventilation settings between patients with and without inhalation trauma. Results: A total of 160 patients from 28 ICUs in 16 countries were included. Low VT was used in 74% of patients, median VT size was 7.3 [interquartile range (IQR) 6.2-8.3] mL/kg PBW and did not differ between patients with and without inhalation trauma (p = 0.58). Median VFD-28 was 17 (IQR 0-26), without a difference between ventilation with low or high VT (p = 0.98). All patients were ventilated with PEEP levels ≥5 cmH2O; 80% of patients had maximum airway pressures <30 cmH2O. Conclusion: In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients, irrespective of the presence of inhalation trauma. Use of low VT was not associated with a reduction in VFD-28.

Original languageEnglish (US)
Pages (from-to)698-710
Number of pages13
JournalBurns and Trauma
StatePublished - 2021


  • Critical care
  • Inhalation trauma
  • Lung-protective
  • Mechanical ventilation

ASJC Scopus subject areas

  • Surgery
  • Immunology and Allergy
  • Emergency Medicine
  • Biomedical Engineering
  • Dermatology
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Ventilation practices in burn patients - an international prospective observational cohort study'. Together they form a unique fingerprint.

Cite this