TY - JOUR
T1 - Venous thromboembolism in patients with head and neck cancer after surgery
AU - Thai, Leo
AU - McCarn, Kate
AU - Stott, William
AU - Watts, Tammara
AU - Wax, Mark K.
AU - Andersen, Peter E.
AU - Gross, Neil D.
PY - 2013/1
Y1 - 2013/1
N2 - Background The purpose of this study was to report the incidence of venous thromboembolism (VTE) in patients with head and neck cancer after surgery. Methods This was a single-institution, retrospective cohort: 134 patients underwent resection and simultaneous microvascular reconstruction. The primary endpoint was identification of confirmed or suspicious VTE within 30 days of surgery. Results Two subjects (1.4%) with confirmed VTE (1 pulmonary embolism, 1 deep venous thrombosis) and 6 subjects (4.4%) with suspicious VTE (1 acute respiratory failure, 1 sudden cardiac arrest, and 4 cases of leg edema without imaging) were identified. The strongest predictors of possible VTE were prior VTE (p =.004; odds ratio [OR], 25.11; 95% confidence interval [CI], 1.13-556.40), red cell transfusion (p =.009; OR, 1.80; 95% CI, 1.16-2.80), high body mass index (p =.015, OR, 1.29, 95% CI, 1.05-1.58), and older age (p =.046; OR, 1.10; 95% CI, 1.00-1.19). Conclusion The incidence of VTE in patients with head and neck cancer after resection and microvascular reconstruction ranged from 1.4% to 5.8%.
AB - Background The purpose of this study was to report the incidence of venous thromboembolism (VTE) in patients with head and neck cancer after surgery. Methods This was a single-institution, retrospective cohort: 134 patients underwent resection and simultaneous microvascular reconstruction. The primary endpoint was identification of confirmed or suspicious VTE within 30 days of surgery. Results Two subjects (1.4%) with confirmed VTE (1 pulmonary embolism, 1 deep venous thrombosis) and 6 subjects (4.4%) with suspicious VTE (1 acute respiratory failure, 1 sudden cardiac arrest, and 4 cases of leg edema without imaging) were identified. The strongest predictors of possible VTE were prior VTE (p =.004; odds ratio [OR], 25.11; 95% confidence interval [CI], 1.13-556.40), red cell transfusion (p =.009; OR, 1.80; 95% CI, 1.16-2.80), high body mass index (p =.015, OR, 1.29, 95% CI, 1.05-1.58), and older age (p =.046; OR, 1.10; 95% CI, 1.00-1.19). Conclusion The incidence of VTE in patients with head and neck cancer after resection and microvascular reconstruction ranged from 1.4% to 5.8%.
KW - deep venous thrombosis
KW - pulmonary embolism
KW - squamous cell carcinoma
KW - surgery
KW - venous thromboembolism
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U2 - 10.1002/hed.22920
DO - 10.1002/hed.22920
M3 - Article
C2 - 22302625
AN - SCOPUS:84871247457
SN - 1043-3074
VL - 35
SP - 4
EP - 9
JO - Head and Neck
JF - Head and Neck
IS - 1
ER -