TY - JOUR
T1 - Venezuelan hemorrhagic fever
T2 - Clinical and epidemiological studies of 165 cases
AU - De Manzione, Nuris
AU - Salas, Rosa Alba
AU - Paredes, Hector
AU - Godoy, Oswaldo
AU - Rojas, Luis
AU - Araoz, Francisco
AU - Fulhorst, Charles F.
AU - Ksiazek, Thomas G.
AU - Mills, James N.
AU - Ellis, Barbara A.
AU - Peters, Clarence J.
AU - Tesh, Robert B.
N1 - Funding Information:
Financial support: This work was supported by grants AI-33983 and AI-10894 from the National Institutes of Health and by the Government of the State of Portuguesa. Administrative support for the field studies in Venezuela was provided by the Pan American Health Organization.
PY - 1998
Y1 - 1998
N2 - Epidemiological and clinical data are presented on 165 cases of Venezuelan hemorrhagic fever (VHF), a newly emerging viral zoonosis caused by Guanarito virus (of the family Arenaviridae). The disease is endemic in a relatively circumscribed area of central Venezuela. Since its first recognition in 1989, the incidence of VHF has peaked each year between November and January, during the period of major agricultural activity in the region of endemicity. The majority of cases have involved male agricultural workers. Principal symptoms among the patients with VHF included fever, malaise, headache, arthralgia, sore throat, vomiting, abdominal pain, diarrhea, convulsions, and a variety of hemorrhagic manifestations. The majority of patients also had leukopenia and thrombocytopenia. The overall fatality rate among the 165 cases was 33.3%, despite hospitalization and vigorous supportive care.
AB - Epidemiological and clinical data are presented on 165 cases of Venezuelan hemorrhagic fever (VHF), a newly emerging viral zoonosis caused by Guanarito virus (of the family Arenaviridae). The disease is endemic in a relatively circumscribed area of central Venezuela. Since its first recognition in 1989, the incidence of VHF has peaked each year between November and January, during the period of major agricultural activity in the region of endemicity. The majority of cases have involved male agricultural workers. Principal symptoms among the patients with VHF included fever, malaise, headache, arthralgia, sore throat, vomiting, abdominal pain, diarrhea, convulsions, and a variety of hemorrhagic manifestations. The majority of patients also had leukopenia and thrombocytopenia. The overall fatality rate among the 165 cases was 33.3%, despite hospitalization and vigorous supportive care.
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U2 - 10.1086/516299
DO - 10.1086/516299
M3 - Article
C2 - 9502447
AN - SCOPUS:17344370412
SN - 1058-4838
VL - 26
SP - 308
EP - 313
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 2
ER -