Vascular IL-10: A protective role in preeclampsia

Satyan Kalkunte; Tania Nevers; Wendy E. Norris; Surendra Sharma

doi:10.1016/j.jri.2011.01.009

Vascular IL-10: A protective role in preeclampsia

Satyan Kalkunte, Tania Nevers, Wendy E. Norris, Surendra Sharma

Research output: Contribution to journal › Article › peer-review

Abstract

IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal-fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation.

Original language	English (US)
Pages (from-to)	165-169
Number of pages	5
Journal	Journal of Reproductive Immunology
Volume	88
Issue number	2
DOIs	https://doi.org/10.1016/j.jri.2011.01.009
State	Published - Mar 2011
Externally published	Yes

Keywords

Angiogenesis
IL-10
Immune tolerance
Preeclampsia
Pregnancy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.jri.2011.01.009

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title = "Vascular IL-10: A protective role in preeclampsia",

abstract = "IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal-fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation.",

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AU - Nevers, Tania

AU - Norris, Wendy E.

AU - Sharma, Surendra

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AB - IL-10 is a pregnancy compatible cytokine that plays a vital role in maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the maternal-fetal interface. Recent evidence now suggests that IL-10 is a potent vascular cytokine that can blunt hypertension and inflammation-mediated vascular dysfunction. Thus, a re-evaluation of IL-10 as a cytokine supporting endovascular interactions and angiogenesis as well as blunting hypoxic-injury and preeclampsia-like features is warranted. In this review, we highlight these novel functions of IL-10 and propose that its immune-modulating and vascular functions are mutually inclusive, particularly in the context of normal gestation.

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KW - IL-10

KW - Immune tolerance

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Vascular IL-10: A protective role in preeclampsia

Abstract

Keywords

ASJC Scopus subject areas

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