Variations in cervical IL-10 and IL-8 concentrations throughout gestation in normal pregnancies

Myriam Mondestin-Sorrentino, John C. Smulian, Anthony M. Vintzileos, David Sorrentino, Cande V. Ananth, Surendra Sharma, Nazeeh N. Hanna

Research output: Contribution to journalArticlepeer-review


Problem: Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited. Methodod study: This was across sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova. Results: The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210-4100), 2460 (1047-4688), 3660 (1451-4748) (P < 0.0021); the median (range) IL-10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8-227.9), 10.9 (0-263.3), 9.5 (0-35.6); the mean IL10/IL-8 × 100 (+/-standard deviation) concentrations were: 3.33 ± 0.65, 1.47 ± 0.41, 0.38 ± 0.52 (P = 0.0035) during the first, second and third trimesters, respectively. Conclusion: The patterns of cervical IL-8 concentration is inversely related to gestational age, and the ratio of IL-10/IL-8 decreases with advancing gestation.

Original languageEnglish (US)
Pages (from-to)482-487
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Issue number6
StatePublished - Jun 2007
Externally publishedYes


  • Cervical IL-8
  • CervicalIL-10
  • Gestational age
  • IL10/IL8 ratio
  • Pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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