TY - JOUR
T1 - Validation in volunteers of a near-infrared spectroscope for monitoring brain oxygenation in vivo
AU - Pollard, Valerie
AU - Prough, Donald S.
AU - Eric DeMelo, A.
AU - Deyo, Donald
AU - Uchida, Tatsuo
AU - Stoddart, Hugh F.
PY - 1996
Y1 - 1996
N2 - Cerebral oximeters based on near-infrared spectroscopy may provide a continuous, noninvasive assessment of cerebral oxygenation. We evaluated a prototype cerebral oximeter (Invos 3100; Somanetics, Troy, MI) in 22 conscious, healthy volunteers breathing hypoxic gas mixtures. Using the first 12 subjects (training group), we developed an algorithm based on the mathematic relationship that converts detected light from the field surveyed by the probe to cerebral hemoglobin oxygen saturation (CS(f)O 2). To develop the algorithm, we correlated the oximeter result with the estimated combined brain hemoglobin oxygen saturation (CS(comb)O 2, where CS(comb)O 2 = S(a)O 2 x 0.25 + S(j)O 2 x 0.75 and S(i)O 2 = jugular venous saturation). We then validated the algorithm in the remaining 10 volunteers (validation group). A close association (r 2 = 0.7980.987 for individuals in the training group and r 2 = 0.794-0.992 for individuals in the validation group) existed between CS(f)O 2 and Cs(comb)O 2. We conclude that continuous monitoring with cerebral oximetry may accurately recognize decreasing cerebral hemoglobin oxygen saturation produced by systemic hypoxemia.
AB - Cerebral oximeters based on near-infrared spectroscopy may provide a continuous, noninvasive assessment of cerebral oxygenation. We evaluated a prototype cerebral oximeter (Invos 3100; Somanetics, Troy, MI) in 22 conscious, healthy volunteers breathing hypoxic gas mixtures. Using the first 12 subjects (training group), we developed an algorithm based on the mathematic relationship that converts detected light from the field surveyed by the probe to cerebral hemoglobin oxygen saturation (CS(f)O 2). To develop the algorithm, we correlated the oximeter result with the estimated combined brain hemoglobin oxygen saturation (CS(comb)O 2, where CS(comb)O 2 = S(a)O 2 x 0.25 + S(j)O 2 x 0.75 and S(i)O 2 = jugular venous saturation). We then validated the algorithm in the remaining 10 volunteers (validation group). A close association (r 2 = 0.7980.987 for individuals in the training group and r 2 = 0.794-0.992 for individuals in the validation group) existed between CS(f)O 2 and Cs(comb)O 2. We conclude that continuous monitoring with cerebral oximetry may accurately recognize decreasing cerebral hemoglobin oxygen saturation produced by systemic hypoxemia.
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U2 - 10.1097/00000539-199602000-00010
DO - 10.1097/00000539-199602000-00010
M3 - Article
C2 - 8561326
AN - SCOPUS:0030059050
SN - 0003-2999
VL - 82
SP - 269
EP - 277
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 2
ER -