Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Pawel Goluszko; Elzbieta Goluszko; Bogdan Nowicki; Stella Nowicki; Vsevolod Popov; Hui Qun Wang

doi:10.1128/IAI.73.1.627-631.2005

Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Pawel Goluszko, Elzbieta Goluszko, Bogdan Nowicki, Stella Nowicki, Vsevolod Popov, Hui Qun Wang

Pathology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

Original language	English (US)
Pages (from-to)	627-631
Number of pages	5
Journal	Infection and immunity
Volume	73
Issue number	1
DOIs	https://doi.org/10.1128/IAI.73.1.627-631.2005
State	Published - Jan 2005

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.1.627-631.2005

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abstract = "The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.",

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AU - Goluszko, Pawel

AU - Goluszko, Elzbieta

AU - Nowicki, Bogdan

AU - Nowicki, Stella

AU - Popov, Vsevolod

AU - Wang, Hui Qun

PY - 2005/1

Y1 - 2005/1

N2 - The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

AB - The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.

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Vaccination with purified Dr fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin

Abstract

ASJC Scopus subject areas

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