Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery

Bernard Choi; Thomas E. Milner; Jeehyun Kim; Jared N. Goodman; Gracie Vargas; Guillermo Aguilar; J. Stuart Nelson

doi:10.1117/1.1648647

Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery

Bernard Choi, Thomas E. Milner, Jeehyun Kim, Jared N. Goodman, Gracie Vargas, Guillermo Aguilar, J. Stuart Nelson

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The use of optical coherence tomography (OCT) for imaging skin during cryosurgery is evaluated. OCT provides high spatial resolution (5-10μm) images of optical backscattering due to local variations in refractive index, such as the boundary between liquid and frozen water in tissue. Time resolved OCT images were acquired during freezing of water, Intralipid^™, and in vivo hamster skin. Subsurface morphological changes were evident only during freezing of Intralipid and skin. A simple thermal model was applied which predicted freezing times on the same order of magnitude as those observed in OCT images. OCT can be used as a feedback tool during cryosurgical procedures to monitor progression of the freezing front.

Original language	English (US)
Pages (from-to)	282-286
Number of pages	5
Journal	Journal of Biomedical Optics
Volume	9
Issue number	2
DOIs	https://doi.org/10.1117/1.1648647
State	Published - Mar 2004
Externally published	Yes

Keywords

Biomedical optical imaging
Hamster window model
Skin flap model
Tissue phantoms

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

Access to Document

10.1117/1.1648647

Cite this

@article{0d8e7a344f5a4f44a56a158c11a1a23d,

title = "Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery",

abstract = "The use of optical coherence tomography (OCT) for imaging skin during cryosurgery is evaluated. OCT provides high spatial resolution (5-10μm) images of optical backscattering due to local variations in refractive index, such as the boundary between liquid and frozen water in tissue. Time resolved OCT images were acquired during freezing of water, Intralipid{\texttrademark}, and in vivo hamster skin. Subsurface morphological changes were evident only during freezing of Intralipid and skin. A simple thermal model was applied which predicted freezing times on the same order of magnitude as those observed in OCT images. OCT can be used as a feedback tool during cryosurgical procedures to monitor progression of the freezing front.",

keywords = "Biomedical optical imaging, Hamster window model, Skin flap model, Tissue phantoms",

author = "Bernard Choi and Milner, {Thomas E.} and Jeehyun Kim and Goodman, {Jared N.} and Gracie Vargas and Guillermo Aguilar and Nelson, {J. Stuart}",

note = "Funding Information: The authors thank Taner Akkin and Woonggyu Jung for technical assistance with OCT imaging, Chris Rylander for his help with the experiments, and Dr. Kristen Kelly and Dr. A. J. Welch for helpful comments. This project was supported in part by research grants awarded by the National Institutes of Health to three of the authors (G.A., Grant No. HD 42057, T.E.M., Grant No. RR 14069, and J.S.N., Grant No. GM 62177). One of the authors (B.C.) acknowledges support by the Arnold and Mabel Beckman Fellows Program. Institutional support was provided by the Office of Naval Research, National Institutes of Health, and the Beckman Laser Institute and Medical Clinic Endowment.",

year = "2004",

month = mar,

doi = "10.1117/1.1648647",

language = "English (US)",

volume = "9",

pages = "282--286",

journal = "Journal of Biomedical Optics",

issn = "1083-3668",

publisher = "SPIE",

number = "2",

}

TY - JOUR

T1 - Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery

AU - Choi, Bernard

AU - Milner, Thomas E.

AU - Kim, Jeehyun

AU - Goodman, Jared N.

AU - Vargas, Gracie

AU - Aguilar, Guillermo

AU - Nelson, J. Stuart

N1 - Funding Information: The authors thank Taner Akkin and Woonggyu Jung for technical assistance with OCT imaging, Chris Rylander for his help with the experiments, and Dr. Kristen Kelly and Dr. A. J. Welch for helpful comments. This project was supported in part by research grants awarded by the National Institutes of Health to three of the authors (G.A., Grant No. HD 42057, T.E.M., Grant No. RR 14069, and J.S.N., Grant No. GM 62177). One of the authors (B.C.) acknowledges support by the Arnold and Mabel Beckman Fellows Program. Institutional support was provided by the Office of Naval Research, National Institutes of Health, and the Beckman Laser Institute and Medical Clinic Endowment.

PY - 2004/3

Y1 - 2004/3

N2 - The use of optical coherence tomography (OCT) for imaging skin during cryosurgery is evaluated. OCT provides high spatial resolution (5-10μm) images of optical backscattering due to local variations in refractive index, such as the boundary between liquid and frozen water in tissue. Time resolved OCT images were acquired during freezing of water, Intralipid™, and in vivo hamster skin. Subsurface morphological changes were evident only during freezing of Intralipid and skin. A simple thermal model was applied which predicted freezing times on the same order of magnitude as those observed in OCT images. OCT can be used as a feedback tool during cryosurgical procedures to monitor progression of the freezing front.

AB - The use of optical coherence tomography (OCT) for imaging skin during cryosurgery is evaluated. OCT provides high spatial resolution (5-10μm) images of optical backscattering due to local variations in refractive index, such as the boundary between liquid and frozen water in tissue. Time resolved OCT images were acquired during freezing of water, Intralipid™, and in vivo hamster skin. Subsurface morphological changes were evident only during freezing of Intralipid and skin. A simple thermal model was applied which predicted freezing times on the same order of magnitude as those observed in OCT images. OCT can be used as a feedback tool during cryosurgical procedures to monitor progression of the freezing front.

KW - Biomedical optical imaging

KW - Hamster window model

KW - Skin flap model

KW - Tissue phantoms

UR - http://www.scopus.com/inward/record.url?scp=2442699191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442699191&partnerID=8YFLogxK

U2 - 10.1117/1.1648647

DO - 10.1117/1.1648647

M3 - Article

C2 - 15065892

AN - SCOPUS:2442699191

SN - 1083-3668

VL - 9

SP - 282

EP - 286

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 2

ER -

Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this