TY - JOUR
T1 - Urea and protein metabolism in burned children
T2 - Effect of dietary protein intake
AU - Patterson, Bruce W.
AU - Nguyen, Thuan
AU - Pierre, Edgar
AU - Herndon, David N.
AU - Wolfe, Robert R.
N1 - Funding Information:
From the Metabolism Unit, Shriners Burns Institute, Galveston; and the Department of Surgery, University of Texas Medical Branch, Galveston, TX. Submitted September 6, 1996; accepted October 26, 1996. Supported by Grants No. 15856 and 15849 from the Shriners Hospitals for Crippled Children. Presented previously in abstract form at the 27th Annual Meeting of the American Burn Association, April 19-22, 1995, Albuquerque, NM. Present address: B. W..P., Department of Internal Medicine, Washington University School of Medicine, 660 S EuclM Ave, Box 8127, St Louis, MO 63110-1093; T.N., Department of Surgery, University of Southern California. Address reprint requests to Robert R. Wolfe, PhD, Metabolism Unit, Shriners Burns Institute, 815 Market St, Galveston, TX 77550. Copyright © 1997by W.B. Saunders Company 0026-0495/97/4605-0018503.00/0
PY - 1997
Y1 - 1997
N2 - The response of urea metabolic kinetics, the rate of whole-body protein breakdown, and muscle and skin protein synthesis rates to dietary protein intake (1.15 to 2.92 g/kg/d) was assessed in children with 20% to 40% total body surface area burn injury using a primed continuous infusion of 15N2- urea and L-13C6-phenylalanine. Plasma urea concentration, production, and excretion rates increased with dietary protein intake without evidence of approaching maximum plateau values. There was no consistent evidence of urea recycling in these subjects (urea production = excretion) at any level of protein intake. The rate of appearance (Ra) of phenylalanine (an index of whole-body protein breakdown) and rate of muscle protein synthesis were independent of dietary protein, whereas there was a significant increase in skin protein synthesis with higher protein intake. We conclude that there seems to be little benefit of high protein intake on whole-body protein breakdown end muscle protein synthesis rates in these burn patients, although high-protein diets may enhance wound healing.
AB - The response of urea metabolic kinetics, the rate of whole-body protein breakdown, and muscle and skin protein synthesis rates to dietary protein intake (1.15 to 2.92 g/kg/d) was assessed in children with 20% to 40% total body surface area burn injury using a primed continuous infusion of 15N2- urea and L-13C6-phenylalanine. Plasma urea concentration, production, and excretion rates increased with dietary protein intake without evidence of approaching maximum plateau values. There was no consistent evidence of urea recycling in these subjects (urea production = excretion) at any level of protein intake. The rate of appearance (Ra) of phenylalanine (an index of whole-body protein breakdown) and rate of muscle protein synthesis were independent of dietary protein, whereas there was a significant increase in skin protein synthesis with higher protein intake. We conclude that there seems to be little benefit of high protein intake on whole-body protein breakdown end muscle protein synthesis rates in these burn patients, although high-protein diets may enhance wound healing.
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U2 - 10.1016/S0026-0495(97)90196-7
DO - 10.1016/S0026-0495(97)90196-7
M3 - Article
C2 - 9160826
AN - SCOPUS:0030973136
SN - 0026-0495
VL - 46
SP - 573
EP - 578
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 5
ER -