TY - JOUR
T1 - Uncommon gnaq, MMP8, AKT3, EGFR, and PIK3R1 mutations in thyroid cancers
AU - Murugan, Avaniyapuram Kannan
AU - Dong, Jianli
AU - Xie, Jingwu
AU - Xing, Mingzhao
N1 - Funding Information:
Funding This study was supported by the NIH grant R01CA134225 to M. Xing.
PY - 2011/6
Y1 - 2011/6
N2 - Frequent mutations in the GNAQ, MMP8, Akt3, EGFR, and PIK3R1 genes have been reported in human cancers but mostly have not been well examined in thyroid cancer. Selected exons of GNAQ, MMP8, AKT3, EGFR, and PIK3R1 genes were sequenced in various thyroid cancers. We found a G2203A EGFR mutation, resulting in a G735S amino acid change, in one of 21 (5%) papillary thyroid cancer samples. We did not find any mutation in the MMP8 gene, but observed a frequent SNP A259G (K87E) genotype switch in various types of thyroid cancer samples. We did not find any mutation in the GNAQ, AKT3, and PIK3R1genes in various types of thyroid cancer. No mutation in these genes was found in 12 cell lines derived from various types of thyroid cancer. Therefore, unlike in other cancers, mutations in these genes are uncommon in thyroid cancer.
AB - Frequent mutations in the GNAQ, MMP8, Akt3, EGFR, and PIK3R1 genes have been reported in human cancers but mostly have not been well examined in thyroid cancer. Selected exons of GNAQ, MMP8, AKT3, EGFR, and PIK3R1 genes were sequenced in various thyroid cancers. We found a G2203A EGFR mutation, resulting in a G735S amino acid change, in one of 21 (5%) papillary thyroid cancer samples. We did not find any mutation in the MMP8 gene, but observed a frequent SNP A259G (K87E) genotype switch in various types of thyroid cancer samples. We did not find any mutation in the GNAQ, AKT3, and PIK3R1genes in various types of thyroid cancer. No mutation in these genes was found in 12 cell lines derived from various types of thyroid cancer. Therefore, unlike in other cancers, mutations in these genes are uncommon in thyroid cancer.
KW - AKT3
KW - EGFR
KW - GNAQ
KW - MMP8
KW - PIK3R1
KW - Thyroid cancer
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U2 - 10.1007/s12022-011-9155-x
DO - 10.1007/s12022-011-9155-x
M3 - Article
C2 - 21487925
AN - SCOPUS:80051699020
SN - 1046-3976
VL - 22
SP - 97
EP - 102
JO - Endocrine Pathology
JF - Endocrine Pathology
IS - 2
ER -