Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle

Alyne K. Harrison; Frederick A. Murphy; G. William Gary

doi:10.1016/0014-4800(71)90050-5

Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle

Alyne K. Harrison, Frederick A. Murphy, G. William Gary

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22 Scopus citations

Abstract

Electron microscopic examination of Coxsackie A4 virus-infected hind limb muscles of suckling mice showed generalized myositis with almost total loss of normal muscle cell architecture. Degenerative changes included dilatation of sarcoplasmic reticulum with concurrent disruption of myofibrils, presenting the appearance of dense amorphous masses in some areas; large accumulations of membrane-bound vesicles; swelling, distortion, and mineralization of mitochondria; increase in lipid deposits; pyknosis of the nuclei; edema and inflammatory infiltration. Virus particles were present in a number of different configurations in muscle fibers: individual particles or small accumulations within vacuoles, two-dimensional linear arrays between membranes, and three-dimensional crystalline arrays, usually in close apposition to sarcoplasmic reticulum or sarcolemma.

Original language	English (US)
Pages (from-to)	30-42
Number of pages	13
Journal	Experimental and Molecular Pathology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/0014-4800(71)90050-5
State	Published - Feb 1971
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Clinical Biochemistry

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title = "Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle",

abstract = "Electron microscopic examination of Coxsackie A4 virus-infected hind limb muscles of suckling mice showed generalized myositis with almost total loss of normal muscle cell architecture. Degenerative changes included dilatation of sarcoplasmic reticulum with concurrent disruption of myofibrils, presenting the appearance of dense amorphous masses in some areas; large accumulations of membrane-bound vesicles; swelling, distortion, and mineralization of mitochondria; increase in lipid deposits; pyknosis of the nuclei; edema and inflammatory infiltration. Virus particles were present in a number of different configurations in muscle fibers: individual particles or small accumulations within vacuoles, two-dimensional linear arrays between membranes, and three-dimensional crystalline arrays, usually in close apposition to sarcoplasmic reticulum or sarcolemma.",

author = "Harrison, {Alyne K.} and Murphy, {Frederick A.} and {William Gary}, G.",

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T1 - Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle

AU - Harrison, Alyne K.

AU - Murphy, Frederick A.

AU - William Gary, G.

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N2 - Electron microscopic examination of Coxsackie A4 virus-infected hind limb muscles of suckling mice showed generalized myositis with almost total loss of normal muscle cell architecture. Degenerative changes included dilatation of sarcoplasmic reticulum with concurrent disruption of myofibrils, presenting the appearance of dense amorphous masses in some areas; large accumulations of membrane-bound vesicles; swelling, distortion, and mineralization of mitochondria; increase in lipid deposits; pyknosis of the nuclei; edema and inflammatory infiltration. Virus particles were present in a number of different configurations in muscle fibers: individual particles or small accumulations within vacuoles, two-dimensional linear arrays between membranes, and three-dimensional crystalline arrays, usually in close apposition to sarcoplasmic reticulum or sarcolemma.

AB - Electron microscopic examination of Coxsackie A4 virus-infected hind limb muscles of suckling mice showed generalized myositis with almost total loss of normal muscle cell architecture. Degenerative changes included dilatation of sarcoplasmic reticulum with concurrent disruption of myofibrils, presenting the appearance of dense amorphous masses in some areas; large accumulations of membrane-bound vesicles; swelling, distortion, and mineralization of mitochondria; increase in lipid deposits; pyknosis of the nuclei; edema and inflammatory infiltration. Virus particles were present in a number of different configurations in muscle fibers: individual particles or small accumulations within vacuoles, two-dimensional linear arrays between membranes, and three-dimensional crystalline arrays, usually in close apposition to sarcoplasmic reticulum or sarcolemma.

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Ultrastructural pathology of coxsackie A4 virus infection of mouse striated muscle

Abstract

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