Two-Photon Detection of Organotin Schiff Base Complexes in Cancer Cells

Jessica C. Berrones-Reyes, Blanca M. Muñoz-Flores, Ashanti Concepción Uscanga-Palomeque, Rosa Santillán, Casiano Del Angel-Mosqueda, David Nobis, Max A. Cochrane, Steven W. Magennis, Víctor M. Jiménez-Pérez

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The early detection of cancer cells and their visualization before and after surgery are essential for successful pre- and post-operative disease management. Although fluorescence imaging is a sensitive and versatile tool that is finding increasing use in clinical applications, there is a lack of tumour-targeting fluorophores. We report here a family of fluorescent Schiff base organotin dyes (1: Et2N−L-SnPh2, 2: Et2N−L-SnBu2, 3: MeO−L-SnPh2, 4: MeO−L-SnBu2, 5: HO−L-SnPh2, and 6: HO−L-SnBu2, where L=2-hydroxybenzylidene-4-hydroxybenzhydrazine). In addition to one-photon-excited fluorescence, efficient two-photon excitation was demonstrated in compounds 1–4. Two of the compounds (5 and 6), both with hydroxyl substituents, were capable of selective accumulation in HeLa cells, allowing differentiation from normal cells (periodontal ligament cells). Compounds 1 and 3 showed excellent cancer cell staining (HeLa) using two-photon bioimaging, which is promising for biomedicine applications.

Original languageEnglish (US)
Pages (from-to)1623-1627
Number of pages5
Issue number5
StatePublished - Feb 7 2020
Externally publishedYes


  • Organotin
  • cancer detection
  • fluorescent bioimaging
  • two-photon excitation

ASJC Scopus subject areas

  • General Chemistry


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