Tumor necrosis factor-alpha converting enzyme: Implications for ocular inflammatory diseases

Kota V. Ramana

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


Tumor necrosis factor-alpha (TNF-α) converting enzyme (TACE), a member of the family of metalloproteinase disintegrin proteins, is responsible for the conversion of inactive TNF-α precursor form to active mature form. TNF-α is a pleiotropic cytokine that contributes to cellular immunity and inflammatory response in wide range of inflammatory pathologies. Although a large number of studies indicate the use of TACE inhibitors, which prevents processing of TNF-α as potential therapeutic drugs for the treatment of inflammatory diseases including rheumatoid arthritis, Crohn's disease and cancer, very few studies indicate its use in ocular pathologies. It is still not clearly understood how the TACE-mediated shedding of cytokines and growth factors in various ocular tissues plays a critical role in the cytotoxic signals causing tissue dysfunction and damage leading to blindness. Regulation of TACE activity is likely to have wide implications for ocular immunology and inflammatory diseases. Specifically, since anti-TNF-α therapies have been used to prevent ocular inflammatory complications, the use of TACE inhibitors could be a novel therapeutic approach for ocular inflammatory diseases especially uveitis.

Original languageEnglish (US)
Pages (from-to)1076-1079
Number of pages4
JournalInternational Journal of Biochemistry and Cell Biology
Issue number7
StatePublished - Jul 2010
Externally publishedYes


  • Eye
  • Inflammation
  • TACE
  • TNF-alpha
  • Uveitis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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