TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease

Shafic El Hindi; Jochen Reiser

doi:10.1007/s00467-010-1718-4

TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease

Research output: Contribution to journal › Article › peer-review

Abstract

Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.

Original language	English (US)
Pages (from-to)	1057-1064
Number of pages	8
Journal	Pediatric Nephrology
Volume	26
Issue number	7
DOIs	https://doi.org/10.1007/s00467-010-1718-4
State	Published - Jul 2011
Externally published	Yes

Keywords

Focal segmental glomerulosclerosis
Glomerular disease
Nephrin
Podocyte
Proteinuria
Slit diaphragm
TRPC6

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/s00467-010-1718-4

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abstract = "Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.",

keywords = "Focal segmental glomerulosclerosis, Glomerular disease, Nephrin, Podocyte, Proteinuria, Slit diaphragm, TRPC6",

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AB - Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.

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KW - Glomerular disease

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KW - Proteinuria

KW - Slit diaphragm

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TRPC channel modulation in podocytes-inching toward novel treatments for glomerular disease

Abstract

Keywords

ASJC Scopus subject areas

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