Transmission of oropouche virus from man to hamster by the midge Culicoides paraensis

Francisco P. Pinheiro; Amelia P.A. Travassos Da Rosa; Maria L.C. Gomes; James W. LeDuc; Alfred L. Hoch

doi:10.1126/science.6800036

Transmission of oropouche virus from man to hamster by the midge Culicoides paraensis

Francisco P. Pinheiro, Amelia P.A. Travassos Da Rosa, Maria L.C. Gomes, James W. LeDuc, Alfred L. Hoch

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Abstract

Oropouche virus (arbovirus family Bunyaviridae, Simbu serological group) was experimentally transmitted from man to hamster by the bite of the midge Culicoides paraensis. Infection rates and transmission rates were determined after the midge had engorged on patients with viremia. The threshold titer necessary to enable infection or transmission by the midges was approximately 5.3 log₁₀ of the median lethal dose of the virus in suckling mice per milliliter of blood. Transmission was achieved 6 to 12 days after C. paraensis had taken the infective blood meal. This represents conclusive evidence of transmission of an arbovirus of public health importance to man by a member of the Ceratopogonidae family.

Original language	English (US)
Pages (from-to)	1251-1253
Number of pages	3
Journal	Science
Volume	215
Issue number	4537
DOIs	https://doi.org/10.1126/science.6800036
State	Published - 1982
Externally published	Yes

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title = "Transmission of oropouche virus from man to hamster by the midge Culicoides paraensis",

abstract = "Oropouche virus (arbovirus family Bunyaviridae, Simbu serological group) was experimentally transmitted from man to hamster by the bite of the midge Culicoides paraensis. Infection rates and transmission rates were determined after the midge had engorged on patients with viremia. The threshold titer necessary to enable infection or transmission by the midges was approximately 5.3 log10 of the median lethal dose of the virus in suckling mice per milliliter of blood. Transmission was achieved 6 to 12 days after C. paraensis had taken the infective blood meal. This represents conclusive evidence of transmission of an arbovirus of public health importance to man by a member of the Ceratopogonidae family.",

author = "Pinheiro, {Francisco P.} and {Travassos Da Rosa}, {Amelia P.A.} and Gomes, {Maria L.C.} and LeDuc, {James W.} and Hoch, {Alfred L.}",

year = "1982",

doi = "10.1126/science.6800036",

language = "English (US)",

volume = "215",

pages = "1251--1253",

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TY - JOUR

T1 - Transmission of oropouche virus from man to hamster by the midge Culicoides paraensis

AU - Pinheiro, Francisco P.

AU - Travassos Da Rosa, Amelia P.A.

AU - Gomes, Maria L.C.

AU - LeDuc, James W.

AU - Hoch, Alfred L.

PY - 1982

Y1 - 1982

N2 - Oropouche virus (arbovirus family Bunyaviridae, Simbu serological group) was experimentally transmitted from man to hamster by the bite of the midge Culicoides paraensis. Infection rates and transmission rates were determined after the midge had engorged on patients with viremia. The threshold titer necessary to enable infection or transmission by the midges was approximately 5.3 log10 of the median lethal dose of the virus in suckling mice per milliliter of blood. Transmission was achieved 6 to 12 days after C. paraensis had taken the infective blood meal. This represents conclusive evidence of transmission of an arbovirus of public health importance to man by a member of the Ceratopogonidae family.

AB - Oropouche virus (arbovirus family Bunyaviridae, Simbu serological group) was experimentally transmitted from man to hamster by the bite of the midge Culicoides paraensis. Infection rates and transmission rates were determined after the midge had engorged on patients with viremia. The threshold titer necessary to enable infection or transmission by the midges was approximately 5.3 log10 of the median lethal dose of the virus in suckling mice per milliliter of blood. Transmission was achieved 6 to 12 days after C. paraensis had taken the infective blood meal. This represents conclusive evidence of transmission of an arbovirus of public health importance to man by a member of the Ceratopogonidae family.

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Transmission of oropouche virus from man to hamster by the midge Culicoides paraensis

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