Transfected Human β-Polymerase Promoter Contains a ras-Responsive Element

Padmini S. Kedar; Douglas R. Lowy; Steven G. Widen; Samuel H. Wilson

Transfected Human β-Polymerase Promoter Contains a ras-Responsive Element

Padmini S. Kedar, Douglas R. Lowy, Steven G. Widen, Samuel H. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21^v-rasH expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

Original language	English (US)
Pages (from-to)	3852-3856
Number of pages	5
Journal	Molecular and cellular biology
Volume	10
Issue number	7
State	Published - Jul 1990
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Cite this

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abstract = "β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21v-rasH expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.",

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AU - Kedar, Padmini S.

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AU - Wilson, Samuel H.

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AB - β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21v-rasH expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

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Transfected Human β-Polymerase Promoter Contains a ras-Responsive Element

Abstract

ASJC Scopus subject areas

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