Transfected Human β-Polymerase Promoter Contains a ras-Responsive Element

Padmini S. Kedar, Douglas R. Lowy, Steven G. Widen, Samuel H. Wilson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


β-Polymerase is a vertebrate cellular DNA polymerase involved in gap-filling synthesis during some types of genomic DNA repair. We report that a cloned human β-polymerase promoter in a transient expression assay is activated by p21v-rasH expression in NIH 3T3 cells. A decanucleotide palindromic element, GTGACGTCAC, at positions -49 to -40 in the promoter is required for this ras-mediated stimulation.

Original languageEnglish (US)
Pages (from-to)3852-3856
Number of pages5
JournalMolecular and cellular biology
Issue number7
StatePublished - Jul 1990
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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