TY - JOUR
T1 - Transcriptomics of intracranial aneurysms
T2 - current state and opportunities in flow diversion
AU - Srinivasan, Visish M.
AU - Shekhtman, Oleg
AU - Kandregula, Sandeep
AU - Mannam, Sneha Sai
AU - Charles Yu, Ling Fai
AU - Kan, Peter
N1 - Publisher Copyright:
© 2024 American Association of Neurological Surgeons. All rights reserved.
PY - 2024/5
Y1 - 2024/5
N2 - Over the last 2 decades, the field of transcriptomics has emerged as a major subdiscipline in biology. Transcriptomic techniques have been used by many groups over this time to better understand intracranial aneurysm development, rupture, and treatment. However, only a few studies have applied transcriptomics to understand the mechanisms behind flow diversion (FD) specifically, despite its increasing importance in the neurointerventional armamentarium. FD is an increasingly safe and effective treatment option for intracranial aneurysms. However, the clinical understanding and use of FD has far outpaced the understanding of the underlying mechanisms. To make FD more predictable, clinically efficacious, and safe, it is important to understand the biological mechanisms at play that lead to successful and unsuccessful FD. In this review, the authors focus on the current understanding of FD biology, the recent advances in transcriptomics, and what future studies could be performed to deepen the understanding of FD. They propose the new concept of the FD microenvironment to be studied, which may unlock a deeper biological understanding. This review provides the background for prospective studies into the development of targeted aneurysm therapy, whether by modified devices or by medical adjuncts.
AB - Over the last 2 decades, the field of transcriptomics has emerged as a major subdiscipline in biology. Transcriptomic techniques have been used by many groups over this time to better understand intracranial aneurysm development, rupture, and treatment. However, only a few studies have applied transcriptomics to understand the mechanisms behind flow diversion (FD) specifically, despite its increasing importance in the neurointerventional armamentarium. FD is an increasingly safe and effective treatment option for intracranial aneurysms. However, the clinical understanding and use of FD has far outpaced the understanding of the underlying mechanisms. To make FD more predictable, clinically efficacious, and safe, it is important to understand the biological mechanisms at play that lead to successful and unsuccessful FD. In this review, the authors focus on the current understanding of FD biology, the recent advances in transcriptomics, and what future studies could be performed to deepen the understanding of FD. They propose the new concept of the FD microenvironment to be studied, which may unlock a deeper biological understanding. This review provides the background for prospective studies into the development of targeted aneurysm therapy, whether by modified devices or by medical adjuncts.
KW - RNA seqencing
KW - aneurysm
KW - cerebrovascular
KW - flow diversion
KW - gene expression
KW - transcriptome
KW - vascular disorders
UR - http://www.scopus.com/inward/record.url?scp=85192112590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85192112590&partnerID=8YFLogxK
U2 - 10.3171/2023.9.JNS23565
DO - 10.3171/2023.9.JNS23565
M3 - Review article
C2 - 37976505
AN - SCOPUS:85192112590
SN - 0022-3085
VL - 140
SP - 1335
EP - 1343
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 5
ER -