Transcranial Doppler measurements in migraine and nitroglycerin headache

Mounzer Y. Kassab, Arshad Majid, Omid Bakhtar, Muhammad U. Farooq, Kamakshi Patel, Edward M. Bednarczyk

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalJournal of Headache and Pain
Issue number5
StatePublished - Oct 2007
Externally publishedYes


  • Flow velocity
  • Headache
  • Migraine
  • Nitroglycerin
  • Pulsatility index
  • Transcranial Doppler

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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