Transcranial Doppler measurements in migraine and nitroglycerin headache

Mounzer Y. Kassab; Arshad Majid; Omid Bakhtar; Muhammad U. Farooq; Kamakshi Patel; Edward M. Bednarczyk

doi:10.1007/s10194-007-0413-8

Transcranial Doppler measurements in migraine and nitroglycerin headache

Mounzer Y. Kassab, Arshad Majid, Omid Bakhtar, Muhammad U. Farooq, Kamakshi Patel, Edward M. Bednarczyk

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.

Original language	English (US)
Pages (from-to)	289-293
Number of pages	5
Journal	Journal of Headache and Pain
Volume	8
Issue number	5
DOIs	https://doi.org/10.1007/s10194-007-0413-8
State	Published - Oct 2007
Externally published	Yes

Keywords

Flow velocity
Headache
Migraine
Nitroglycerin
Pulsatility index
Transcranial Doppler

ASJC Scopus subject areas

Clinical Neurology
Anesthesiology and Pain Medicine

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10.1007/s10194-007-0413-8

Cite this

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title = "Transcranial Doppler measurements in migraine and nitroglycerin headache",

abstract = "The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.",

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AU - Kassab, Mounzer Y.

AU - Majid, Arshad

AU - Bakhtar, Omid

AU - Farooq, Muhammad U.

AU - Patel, Kamakshi

AU - Bednarczyk, Edward M.

PY - 2007/10

Y1 - 2007/10

N2 - The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.

AB - The objective of this study was to examine the cerebral circulation during spontaneous migraine attacks and to compare changes to an experimental headache model induced by nitroglycerin (NTG) infusion. This prospective study was carried out in a tertiary care hospital on migraineurs with or without aura. Healthy volunteers served as controls. There were no interventions. Flow velocity (FV) and pulsatility index (PI) were measured in migraineurs between and during headache attacks. In controls, FV and PI of the middle cerebral arteries were performed at baseline and after each IV infusion of 0.125, 0.25 and 0.5 μg/kg/min of NTG. In migraineurs, a significant increase in the mean flow velocity (MFV) in the left vertebral artery (VA) and the PI of the right VA during spontaneous migraine headache was found. In controls, all FV significantly decreased after infusion of NTG. The NTG model produces expected and substantially different vascular effects than those seen with spontaneous migraine headache.

KW - Flow velocity

KW - Headache

KW - Migraine

KW - Nitroglycerin

KW - Pulsatility index

KW - Transcranial Doppler

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Transcranial Doppler measurements in migraine and nitroglycerin headache

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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