To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators

Stuti K. Desai; Linda J. Kenney

doi:10.1111/mmi.13532

To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators

Stuti K. Desai, Linda J. Kenney

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Bacteria sense and respond to their environment through the use of two-component regulatory systems. The ability to adapt to a wide range of environmental stresses is directly related to the number of two-component systems an organism possesses. Recent advances in this area have identified numerous variations on the archetype systems that employ a sensor kinase and a response regulator. It is now evident that many orphan regulators that lack cognate kinases do not rely on phosphorylation for activation and new roles for unphosphorylated response regulators have been identified. The significance of recent findings and suggestions for further research are discussed.

Original language	English (US)
Pages (from-to)	203-213
Number of pages	11
Journal	Molecular Microbiology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1111/mmi.13532
State	Published - Jan 1 2017
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology

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10.1111/mmi.13532

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To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators

Abstract

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