Tissue oxygen saturation during hyperthermic progressive central hypovolemia

Zachary J. Schlader, Eric Rivas, Babs R. Soller, Victor A. Convertino, Craig G. Crandall

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


During nor-mothermia, a reduction in near-infrared spectroscopy (NIRS)-derived tissue oxygen saturation (So2) is an indicator of central hypovolemia. Hyperthermia increases skin blood flow and reduces tolerance to central hypovolemia, both of which may alter the interpretation of tissue So2 during central hypovolemia. This study tested the hypothesis that maximal reductions in tissue SO2 would be similar throughout normothermic and hyperthermic central hypovolemia to presyncope. Ten healthy males (means ± SD; 32 ± 5 yr) underwent central hypovolemia via progressive lower-body negative pressure (LBNP) to presyncope during normothermia (skin temperature ≈ 34°C) and hyperthermia (+ 1.2 ± 0.1°C increase in internal temperature via a water-perfused suit, skin temperature ≈ 39°C). NIRS-derived forearm (flexor digitorum profundus) tissue So2 was measured throughout and analyzed as the absolute change from pre-LBNP. Hyperthermia reduced (P < 0.001) LBNP tolerance by 49 ± 33% (from 16.7 ± 7.9 to 7.2 ± 3.9 min). Pre-LBNP, tissue SO2 was similar (P = 0.654) between normothermia (74 ± 5%) and hyperthermia (73 ± 7%). Tissue SO2 decreased (P < 0.001) throughout LBNP, but the reduction from pre-LBNP to presyncope was greater during normothermia (— 10 ± 6%) than during hyperthermia (— 6 ± 5%; P = 0.041). Contrary to our hypothesis, these findings indicate that hyperthermia is associated with a smaller maximal reduction in tissue So2 during central hypovolemia to presyncope.

Original languageEnglish (US)
Pages (from-to)R731-R736
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number6
StatePublished - Sep 15 2014
Externally publishedYes


  • Heat stress
  • Lower body negative pressure
  • Simulated hemorrhage
  • Syncope

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Tissue oxygen saturation during hyperthermic progressive central hypovolemia'. Together they form a unique fingerprint.

Cite this