Time-resolved MR angiography of renal artery stenosis in a swine model at 3 Tesla using gadobutrol with digital subtraction angiography correlation

John N. Morelli, Fei Ai, Val M. Runge, Wei Zhang, Xiaoming Li, Peter Schmitt, Gary McNeal, Henrick J. Michaely, Stefan O. Schoenberg, Matthew Miller, Clint M. Gerdes, Spencer T. Sincleair, Heidi Spratt, Ulrike I. Attenberger

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose: To establish the minimum dose required for detection of renal artery stenosis using high temporal resolution, contrast enhanced MR angiography (MRA) in a porcine model. Materials and Methods: Surgically created renal artery stenoses were imaged with 3 Tesla MR and digital subtraction angiography (DSA) in 12 swine in this IACUC approved protocol. Gadobutrol was injected intravenously at doses of 0.5, 1, 2, and 4 mL for time-resolved MRA (1.5 × 1.5 mm2 spatial resolution). Region of interest analysis was performed together with stenosis assessment and qualitative evaluation by two blinded readers. Results: Mean signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were statistically significantly less with the 0.5-mL protocol (P < 0.001). There were no statistically significant differences among the other evaluated doses. Both readers found 10/12 cases with the 0.5-mL protocol to be of inadequate diagnostic quality (K = 1.0). All other scans were found to be adequate for diagnosis. Accuracies in distinguishing between mild/insignificant (<50%) and higher grade stenoses (>50%) were comparable among the higher-dose protocols (sensitivities 73-93%, specificities 62-100%). Conclusion: Renal artery stenosis can be assessed with very low doses (∼0.025 mmol/kg bodyweight) of a high concentration, high relaxivity gadolinium chelate formulation in a swine model, results which are promising with respect to limiting exposure to gadolinium based contrast agents. J. Magn. Reson. Imaging 2012;36:704-713.

Original languageEnglish (US)
Pages (from-to)704-713
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number3
StatePublished - Sep 2012


  • MRA
  • gadobutrol
  • time-resolved MRA

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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