TY - JOUR
T1 - Three-Dimensional NOESY-NOESY Hybrid-Hybrid Matrix Refinement of a DNA Three-Way Junction
AU - Thiviyanthan, Varatharasa
AU - Illangasekare, Nishantha
AU - Gozansky, Elliott
AU - Zhu, Frank
AU - Leontis, Neocles B.
AU - Luxon, Bruce A.
AU - Gorenstein, David G.
PY - 1998
Y1 - 1998
N2 - A computationally efficient hybrid-hybrid relaxation matrix refinement methodology using 3D NOESY-NOESY data is described. The methodology was tested on simulated data, derived from the Dickerson dodecamer, and used to refine the structure of a DNA three way junction from experimentally determined 3D NOESY-NOESY volume data. Our results indicate that the 3D hybrid-hybrid MORASS methodology, by combining the spectral dispersion of 3D NOESY-NOESY spectroscopy and the computational efficiency of 2D refinement programs, provides an accurate and robust means for structure determination of large biomolecules.
AB - A computationally efficient hybrid-hybrid relaxation matrix refinement methodology using 3D NOESY-NOESY data is described. The methodology was tested on simulated data, derived from the Dickerson dodecamer, and used to refine the structure of a DNA three way junction from experimentally determined 3D NOESY-NOESY volume data. Our results indicate that the 3D hybrid-hybrid MORASS methodology, by combining the spectral dispersion of 3D NOESY-NOESY spectroscopy and the computational efficiency of 2D refinement programs, provides an accurate and robust means for structure determination of large biomolecules.
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M3 - Article
AN - SCOPUS:0346615660
SN - 0097-6156
VL - 682
SP - 167
EP - 180
JO - ACS Symposium Series
JF - ACS Symposium Series
ER -