Thiol-functionalized gold nanodots: Two-photon absorption property and imaging in vitro

Chien Liang Liu, Mei Lin Ho, Yu Chun Chen, Cheng Chih Hsieh, Yi Chih Lin, Yu Hsiu Wang, Meng Ju Yang, Hsin Sheng Duan, Bo So Chen, Jyh Fu Lee, Jong Kai Hsiao, Pi Tai Chou

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


We report here the study of two-photon induced luminescence of 11-mercaptoundecanoic acid functionalized quantum-sized Au nanodots (11MUA-Au nanodots). The X-ray absorption near-edge structure (XANES) measurement at the gold LIII edge indicates that the oxidation state of the surface of 11MUA-Au nanodots is best described as Au+. The two-photon absorption (TPA) property of 11MUA-Au nanodots was then investigated via an open aperture Z-scan method. Together with a precise extinction coefficient (i.e., one-photon absorption) extracted from inductively coupled plasma mass spectrometry, the TPA cross section, σ, was deduced to be 8761 ± 175 GM (800 nm) for 11MUA-Au nanodots (diameter 1.33 ± 0.12) in water. Upon dextran encapsulation, 11MUA-Au nanodots was proved to be highly water-soluble, stable, and low in toxicity, which demonstrated its power in two-photon imaging toward human mesenchymal stem cells (hMSCs) in vitro.

Original languageEnglish (US)
Pages (from-to)21082-21089
Number of pages8
JournalJournal of Physical Chemistry C
Issue number50
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Energy
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films


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