Thermodynamics of association to a molecule immobilized in an electric double layer

Arnold Vainrub, B. Montgomery Pettitt

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


A thermodynamic theory of association to a molecule immobilized near a surface has been developed. Exact equations for the binding enthalpy, entropy and equilibrium reaction constant for an immobilized complex are derived. Using linear Poisson-Boltzmann theory of the electric double-layer interaction between an ion-penetrable sphere and a hard plate allows a closed form evaluation. We briefly discuss application of the theory to a DNA chip at high (1 M NaCl) and low (0.01 M NaCl) ionic strength for dielectric and metallic substrates. Predicted strong electrostatic effects suggest the feasibility of electronic control of DNA hybridization and design of chips avoiding the DNA folding problem.

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalChemical Physics Letters
Issue number1-2
StatePublished - Jun 9 2000
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry


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