Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review

Pei Teng Lum, Mahendran Sekar, Siew Hua Gan, Srikanth Jeyabalan, Srinivasa Reddy Bonam, Nur Najihah Izzati Mat Rani, Ku Marina Ku-Mahdzir, Lay Jing Seow, Yuan Seng Wu, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria

Research output: Contribution to journalReview articlepeer-review

Abstract

There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and modulates cell signalling pathways. The purpose of this review provide a brief overview of the in vitro/in vivo reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney disorders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent therapeutic potential in managing kidney disorders. Thus, in addition to this review, in-silico molecular docking is performed against nuclear factor kappa B (NF-κB) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective molecule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-κB and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clinical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disorders in humans.

Original languageEnglish (US)
Pages (from-to)1530-1542
Number of pages13
JournalSaudi Journal of Biological Sciences
Volume29
Issue number3
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • Drug delivery
  • In-silico
  • Kidney disorders
  • Mangifera indica
  • Mangiferin
  • Reno-protective

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences

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