Therapeutic intervention of ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail

James Pettitt, Larry Zeitlin, Do H. Kim, Cara Working, Joshua C. Johnson, Ognian Bohorov, Barry Bratcher, Ernie Hiatt, Steven D. Hume, Ashley K. Johnson, Josh Morton, Michael H. Pauly, Kevin J. Whaley, Michael F. Ingram, Ashley Zovanyi, Megan Heinrich, Ashley Piper, Justine Zelko, Gene G. Olinger

Research output: Contribution to journalArticlepeer-review

Abstract

Ebola virus (EBOV) remains one of the most lethal transmissible infections and is responsible for high fatality rates and substantial morbidity during sporadic outbreaks. With increasing human incursions into endemic regions and the reported possibility of airborne transmission, EBOV is a high-priority public health threat for which no preventive or therapeutic options are currently available. Recent studies have demonstrated that cocktails of monoclonal antibodies are effective at preventing morbidity and mortality in nonhuman primates (NHPs) when administered as a post-exposure prophylactic within 1 or 2 days of challenge. To test whether one of these cocktails (MB-003) demonstrates efficacy as a therapeutic (after the onset of symptoms), we challenged NHPs with EBOV and initiated treatment upon confirmation of infection according to a diagnostic protocol for U.S. Food and Drug Administration Emergency Use Authorization and observation of a documented fever. Of the treated animals, 43% survived challenge, whereas both the controls and all historical controls with the same challenge stock succumbed to infection. These results represent successful therapy of EBOV infection in NHPs.

Original languageEnglish (US)
Article number199ra113
JournalScience Translational Medicine
Volume5
Issue number199
DOIs
StatePublished - Aug 21 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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