Abstract
Systemic administration of MSCs resulted in remarkable functional improvements in injured tissues without either long-term engraftment or differentiation in many clinical and experimental situations. Emerging evidence suggest that most of the beneficial effects of MSCs could be explained by secretion of soluble factors that have multiple effects including modulation of inflammatory and immune reactions, protection from cell death, and stimulation of endogenous progenitor cells. In this review, we focus on the therapeutic factors that account for the beneficial effects of MSCs in animal models of human diseases.
Original language | English (US) |
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Pages (from-to) | 3073-3078 |
Number of pages | 6 |
Journal | Journal of Cellular Biochemistry |
Volume | 112 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2011 |
Externally published | Yes |
Keywords
- ADULT PROGENITOR CELLS
- MSCs
- SECRETORY FACTORS
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology