The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Adam A. Dmytriw; Mahmoud Dibas; Sherief Ghozy; Nimer Adeeb; Jose Danilo Bengzon Diestro; Kevin Phan; Hugo H. Cuellar-Saenz; Ahmad Sweid; Sovann V. Lay; Adrien Guenego; Leonardo Renieri; Ali Al Balushi; Guillaume Saliou; Markus Möhlenbruch; Robert W. Regenhardt; Justin E. Vranic; Ivan Lylyk; Paul M. Foreman; Jay A. Vachhani; Vedran Župančić; Muhammad U. Hafeez; Caleb Rutledge; Muhammad Waqas; Vincent M. Tutino; James D. Rabinov; Yifan Ren; Clemens M. Schirmer; Mariangela Piano; Anna L. Kühn; Caterina Michelozzi; Stéphanie Elens; Robert M. Starke; Ameer Hassan; Arsalaan Salehani; Peter Sporns; Jesse Jones; Marios Psychogios; Julian Spears; Boris Lubicz; Pietro Panni; Ajit S. Puri; Guglielmo Pero; Christoph J. Griessenauer; Hamed Asadi; Christopher J. Stapleton; Adnan Siddiqui; Andrew F. Ducruet; Felipe C. Albuquerque; Rose Du; Peter Kan; Vladimir Kalousek; Pedro Lylyk; Srikanth Boddu; Stavropoula Tjoumakaris; Jared Knopman; Mohammad A. Aziz-Sultan; Nicola Limbucci; Pascal Jabbour; Christophe Cognard; Aman B. Patel

doi:10.1007/s12975-022-01072-x

The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Adam A. Dmytriw, Mahmoud Dibas, Sherief Ghozy, Nimer Adeeb, Jose Danilo Bengzon Diestro, Kevin Phan, Hugo H. Cuellar-Saenz, Ahmad Sweid, Sovann V. Lay, Adrien Guenego, Leonardo Renieri, Ali Al Balushi, Guillaume Saliou, Markus Möhlenbruch, Robert W. Regenhardt, Justin E. Vranic, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani, Vedran ŽupančićMuhammad U. Hafeez, Caleb Rutledge, Muhammad Waqas, Vincent M. Tutino, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Mariangela Piano, Anna L. Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M. Starke, Ameer Hassan, Arsalaan Salehani, Peter Sporns, Jesse Jones, Marios Psychogios, Julian Spears, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Christoph J. Griessenauer, Hamed Asadi, Christopher J. Stapleton, Adnan Siddiqui, Andrew F. Ducruet, Felipe C. Albuquerque, Rose Du, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Stavropoula Tjoumakaris, Jared Knopman, Mohammad A. Aziz-Sultan, Nicola Limbucci, Pascal Jabbour, Christophe Cognard, Aman B. Patel

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

Several studies have shown promising outcomes of the Woven EndoBridge (WEB) device for the treatment of wide-necked intracranial bifurcation aneurysms. This is a multicenter study attempts to explore the changes in trends and treatment outcomes over time for WEB embolization of intracranial aneurysms. The WorldWideWEB consortium is a retrospective multicenter collaboration of data from international centers spanning from January 2011 and June 2021, with no limitations on aneurysm location or rupture status. Both bifurcation and sidewall aneurysms were included. These patients were stratified based on treatment year into five treatment intervals: 2011–2015 (N = 66), 2016–2017 (N = 77), 2018 (N = 66), 2019 (N = 300), and 2020–2021 (N = 173). Patient characteristics and angiographic and clinical outcomes were compared between these time intervals. This study comprised 671 patients (median age 61.4 years; 71.2% female) with 682 intracranial aneurysms. Over time, we observed an increasing tendency to treat patients presenting with ruptured aneurysms and aneurysms with smaller neck, diameter, and dome widths. Furthermore, we observed a trend towards more off-label use of the WEB for sidewall aneurysms and increased adoption of transradial access for WEB deployment. Moreover, the proportion of patients with adequate WEB occlusion immediately and at last follow-up was significantly higher in more recent year cohorts, as well as lower rates of compaction and retreatment. Mortality and complications did not differ over time. This learning curve study suggests improved experience using the WEB for the treatment of intracranial aneurysms and has yielded higher rates of adequate occlusion over time.

Original language	English (US)
Pages (from-to)	455-464
Number of pages	10
Journal	Translational Stroke Research
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/s12975-022-01072-x
State	Published - Aug 2023

Keywords

Endovascular
Intracranial aneurysm
Intrasaccular
Learning curve
WEB
Woven EndoBridge

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology
Cardiology and Cardiovascular Medicine

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Dmytriw, A. A., Dibas, M., Ghozy, S., Adeeb, N., Diestro, J. D. B., Phan, K., Cuellar-Saenz, H. H., Sweid, A., Lay, S. V., Guenego, A., Renieri, L., Al Balushi, A., Saliou, G., Möhlenbruch, M., Regenhardt, R. W., Vranic, J. E., Lylyk, I., Foreman, P. M., Vachhani, J. A., ... Patel, A. B. (2023). The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium. Translational Stroke Research, 14(4), 455-464. https://doi.org/10.1007/s12975-022-01072-x

Dmytriw, AA, Dibas, M, Ghozy, S, Adeeb, N, Diestro, JDB, Phan, K, Cuellar-Saenz, HH, Sweid, A, Lay, SV, Guenego, A, Renieri, L, Al Balushi, A, Saliou, G, Möhlenbruch, M, Regenhardt, RW, Vranic, JE, Lylyk, I, Foreman, PM, Vachhani, JA, Župančić, V, Hafeez, MU, Rutledge, C, Waqas, M, Tutino, VM, Rabinov, JD, Ren, Y, Schirmer, CM, Piano, M, Kühn, AL, Michelozzi, C, Elens, S, Starke, RM, Hassan, A, Salehani, A, Sporns, P, Jones, J, Psychogios, M, Spears, J, Lubicz, B, Panni, P, Puri, AS, Pero, G, Griessenauer, CJ, Asadi, H, Stapleton, CJ, Siddiqui, A, Ducruet, AF, Albuquerque, FC, Du, R, Kan, P, Kalousek, V, Lylyk, P, Boddu, S, Tjoumakaris, S, Knopman, J, Aziz-Sultan, MA, Limbucci, N, Jabbour, P, Cognard, C & Patel, AB 2023, 'The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium', Translational Stroke Research, vol. 14, no. 4, pp. 455-464. https://doi.org/10.1007/s12975-022-01072-x

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title = "The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium",

abstract = "Several studies have shown promising outcomes of the Woven EndoBridge (WEB) device for the treatment of wide-necked intracranial bifurcation aneurysms. This is a multicenter study attempts to explore the changes in trends and treatment outcomes over time for WEB embolization of intracranial aneurysms. The WorldWideWEB consortium is a retrospective multicenter collaboration of data from international centers spanning from January 2011 and June 2021, with no limitations on aneurysm location or rupture status. Both bifurcation and sidewall aneurysms were included. These patients were stratified based on treatment year into five treatment intervals: 2011–2015 (N = 66), 2016–2017 (N = 77), 2018 (N = 66), 2019 (N = 300), and 2020–2021 (N = 173). Patient characteristics and angiographic and clinical outcomes were compared between these time intervals. This study comprised 671 patients (median age 61.4 years; 71.2% female) with 682 intracranial aneurysms. Over time, we observed an increasing tendency to treat patients presenting with ruptured aneurysms and aneurysms with smaller neck, diameter, and dome widths. Furthermore, we observed a trend towards more off-label use of the WEB for sidewall aneurysms and increased adoption of transradial access for WEB deployment. Moreover, the proportion of patients with adequate WEB occlusion immediately and at last follow-up was significantly higher in more recent year cohorts, as well as lower rates of compaction and retreatment. Mortality and complications did not differ over time. This learning curve study suggests improved experience using the WEB for the treatment of intracranial aneurysms and has yielded higher rates of adequate occlusion over time.",

keywords = "Endovascular, Intracranial aneurysm, Intrasaccular, Learning curve, WEB, Woven EndoBridge",

author = "Dmytriw, {Adam A.} and Mahmoud Dibas and Sherief Ghozy and Nimer Adeeb and Diestro, {Jose Danilo Bengzon} and Kevin Phan and Cuellar-Saenz, {Hugo H.} and Ahmad Sweid and Lay, {Sovann V.} and Adrien Guenego and Leonardo Renieri and {Al Balushi}, Ali and Guillaume Saliou and Markus M{\"o}hlenbruch and Regenhardt, {Robert W.} and Vranic, {Justin E.} and Ivan Lylyk and Foreman, {Paul M.} and Vachhani, {Jay A.} and Vedran {\v Z}upan{\v c}i{\'c} and Hafeez, {Muhammad U.} and Caleb Rutledge and Muhammad Waqas and Tutino, {Vincent M.} and Rabinov, {James D.} and Yifan Ren and Schirmer, {Clemens M.} and Mariangela Piano and K{\"u}hn, {Anna L.} and Caterina Michelozzi and St{\'e}phanie Elens and Starke, {Robert M.} and Ameer Hassan and Arsalaan Salehani and Peter Sporns and Jesse Jones and Marios Psychogios and Julian Spears and Boris Lubicz and Pietro Panni and Puri, {Ajit S.} and Guglielmo Pero and Griessenauer, {Christoph J.} and Hamed Asadi and Stapleton, {Christopher J.} and Adnan Siddiqui and Ducruet, {Andrew F.} and Albuquerque, {Felipe C.} and Rose Du and Peter Kan and Vladimir Kalousek and Pedro Lylyk and Srikanth Boddu and Stavropoula Tjoumakaris and Jared Knopman and Aziz-Sultan, {Mohammad A.} and Nicola Limbucci and Pascal Jabbour and Christophe Cognard and Patel, {Aman B.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2023",

month = aug,

doi = "10.1007/s12975-022-01072-x",

language = "English (US)",

volume = "14",

pages = "455--464",

journal = "Translational Stroke Research",

issn = "1868-4483",

publisher = "Springer",

number = "4",

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T1 - The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms

T2 - Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

AU - Dmytriw, Adam A.

AU - Dibas, Mahmoud

AU - Ghozy, Sherief

AU - Adeeb, Nimer

AU - Diestro, Jose Danilo Bengzon

AU - Phan, Kevin

AU - Cuellar-Saenz, Hugo H.

AU - Sweid, Ahmad

AU - Lay, Sovann V.

AU - Guenego, Adrien

AU - Renieri, Leonardo

AU - Al Balushi, Ali

AU - Saliou, Guillaume

AU - Möhlenbruch, Markus

AU - Regenhardt, Robert W.

AU - Vranic, Justin E.

AU - Lylyk, Ivan

AU - Foreman, Paul M.

AU - Vachhani, Jay A.

AU - Župančić, Vedran

AU - Hafeez, Muhammad U.

AU - Rutledge, Caleb

AU - Waqas, Muhammad

AU - Tutino, Vincent M.

AU - Rabinov, James D.

AU - Ren, Yifan

AU - Schirmer, Clemens M.

AU - Piano, Mariangela

AU - Kühn, Anna L.

AU - Michelozzi, Caterina

AU - Elens, Stéphanie

AU - Starke, Robert M.

AU - Hassan, Ameer

AU - Salehani, Arsalaan

AU - Sporns, Peter

AU - Jones, Jesse

AU - Psychogios, Marios

AU - Spears, Julian

AU - Lubicz, Boris

AU - Panni, Pietro

AU - Puri, Ajit S.

AU - Pero, Guglielmo

AU - Griessenauer, Christoph J.

AU - Asadi, Hamed

AU - Stapleton, Christopher J.

AU - Siddiqui, Adnan

AU - Ducruet, Andrew F.

AU - Albuquerque, Felipe C.

AU - Du, Rose

AU - Kan, Peter

AU - Kalousek, Vladimir

AU - Lylyk, Pedro

AU - Boddu, Srikanth

AU - Tjoumakaris, Stavropoula

AU - Knopman, Jared

AU - Aziz-Sultan, Mohammad A.

AU - Limbucci, Nicola

AU - Jabbour, Pascal

AU - Cognard, Christophe

AU - Patel, Aman B.

PY - 2023/8

Y1 - 2023/8

N2 - Several studies have shown promising outcomes of the Woven EndoBridge (WEB) device for the treatment of wide-necked intracranial bifurcation aneurysms. This is a multicenter study attempts to explore the changes in trends and treatment outcomes over time for WEB embolization of intracranial aneurysms. The WorldWideWEB consortium is a retrospective multicenter collaboration of data from international centers spanning from January 2011 and June 2021, with no limitations on aneurysm location or rupture status. Both bifurcation and sidewall aneurysms were included. These patients were stratified based on treatment year into five treatment intervals: 2011–2015 (N = 66), 2016–2017 (N = 77), 2018 (N = 66), 2019 (N = 300), and 2020–2021 (N = 173). Patient characteristics and angiographic and clinical outcomes were compared between these time intervals. This study comprised 671 patients (median age 61.4 years; 71.2% female) with 682 intracranial aneurysms. Over time, we observed an increasing tendency to treat patients presenting with ruptured aneurysms and aneurysms with smaller neck, diameter, and dome widths. Furthermore, we observed a trend towards more off-label use of the WEB for sidewall aneurysms and increased adoption of transradial access for WEB deployment. Moreover, the proportion of patients with adequate WEB occlusion immediately and at last follow-up was significantly higher in more recent year cohorts, as well as lower rates of compaction and retreatment. Mortality and complications did not differ over time. This learning curve study suggests improved experience using the WEB for the treatment of intracranial aneurysms and has yielded higher rates of adequate occlusion over time.

AB - Several studies have shown promising outcomes of the Woven EndoBridge (WEB) device for the treatment of wide-necked intracranial bifurcation aneurysms. This is a multicenter study attempts to explore the changes in trends and treatment outcomes over time for WEB embolization of intracranial aneurysms. The WorldWideWEB consortium is a retrospective multicenter collaboration of data from international centers spanning from January 2011 and June 2021, with no limitations on aneurysm location or rupture status. Both bifurcation and sidewall aneurysms were included. These patients were stratified based on treatment year into five treatment intervals: 2011–2015 (N = 66), 2016–2017 (N = 77), 2018 (N = 66), 2019 (N = 300), and 2020–2021 (N = 173). Patient characteristics and angiographic and clinical outcomes were compared between these time intervals. This study comprised 671 patients (median age 61.4 years; 71.2% female) with 682 intracranial aneurysms. Over time, we observed an increasing tendency to treat patients presenting with ruptured aneurysms and aneurysms with smaller neck, diameter, and dome widths. Furthermore, we observed a trend towards more off-label use of the WEB for sidewall aneurysms and increased adoption of transradial access for WEB deployment. Moreover, the proportion of patients with adequate WEB occlusion immediately and at last follow-up was significantly higher in more recent year cohorts, as well as lower rates of compaction and retreatment. Mortality and complications did not differ over time. This learning curve study suggests improved experience using the WEB for the treatment of intracranial aneurysms and has yielded higher rates of adequate occlusion over time.

KW - Endovascular

KW - Intracranial aneurysm

KW - Intrasaccular

KW - Learning curve

KW - WEB

KW - Woven EndoBridge

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U2 - 10.1007/s12975-022-01072-x

DO - 10.1007/s12975-022-01072-x

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AN - SCOPUS:85137486444

SN - 1868-4483

VL - 14

SP - 455

EP - 464

JO - Translational Stroke Research

JF - Translational Stroke Research

IS - 4

ER -

The Woven EndoBridge (WEB) Device for the Treatment of Intracranial Aneurysms: Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium

Abstract

Keywords

ASJC Scopus subject areas

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