The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Sunil K. Verma; Trivadi S. Ganesan; Uday Kishore; Peter J. Parker

doi:10.1007/s13238-011-1028-z

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Sunil K. Verma, Trivadi S. Ganesan, Uday Kishore, Peter J. Parker

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

Original language	English (US)
Pages (from-to)	237-249
Number of pages	13
Journal	Protein and Cell
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/s13238-011-1028-z
State	Published - Mar 2011
Externally published	Yes

Keywords

Microtubule
Protein-protein interaction
RASSF1A
Rap1A
Vimentin

ASJC Scopus subject areas

Biotechnology
Biochemistry
Drug Discovery
Cell Biology

Access to Document

10.1007/s13238-011-1028-z

Cite this

@article{e23617789a9a4e698b9964878f04d83b,

title = "The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A",

abstract = "Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.",

keywords = "Microtubule, Protein-protein interaction, RASSF1A, Rap1A, Vimentin",

author = "Verma, {Sunil K.} and Ganesan, {Trivadi S.} and Uday Kishore and Parker, {Peter J.}",

year = "2011",

month = mar,

doi = "10.1007/s13238-011-1028-z",

language = "English (US)",

volume = "2",

pages = "237--249",

journal = "Protein and Cell",

issn = "1674-800X",

publisher = "Springer-Verlag GmbH and Co. KG",

number = "3",

}

TY - JOUR

T1 - The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

AU - Verma, Sunil K.

AU - Ganesan, Trivadi S.

AU - Kishore, Uday

AU - Parker, Peter J.

PY - 2011/3

Y1 - 2011/3

N2 - Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

AB - Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

KW - Microtubule

KW - Protein-protein interaction

KW - RASSF1A

KW - Rap1A

KW - Vimentin

UR - http://www.scopus.com/inward/record.url?scp=79960049406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960049406&partnerID=8YFLogxK

U2 - 10.1007/s13238-011-1028-z

DO - 10.1007/s13238-011-1028-z

M3 - Article

C2 - 21468893

AN - SCOPUS:79960049406

SN - 1674-800X

VL - 2

SP - 237

EP - 249

JO - Protein and Cell

JF - Protein and Cell

IS - 3

ER -

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this