The role of biotransformation in chemical induced liver injury

J. R. Mitchell; W. R. Snodgrass; J. R. Gillette

doi:10.1289/ehp.761527

The role of biotransformation in chemical induced liver injury

J. R. Mitchell, W. R. Snodgrass, J. R. Gillette

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The role of drug metabolism in chemical induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

Original language	English (US)
Pages (from-to)	27-38
Number of pages	12
Journal	Environmental health perspectives
Volume	Vol.15
DOIs	https://doi.org/10.1289/ehp.761527
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1289/ehp.761527

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title = "The role of biotransformation in chemical induced liver injury",

abstract = "The role of drug metabolism in chemical induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.",

author = "Mitchell, {J. R.} and Snodgrass, {W. R.} and Gillette, {J. R.}",

year = "1976",

doi = "10.1289/ehp.761527",

language = "English (US)",

volume = "Vol.15",

pages = "27--38",

journal = "Environmental health perspectives",

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AU - Snodgrass, W. R.

AU - Gillette, J. R.

PY - 1976

Y1 - 1976

N2 - The role of drug metabolism in chemical induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

AB - The role of drug metabolism in chemical induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

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DO - 10.1289/ehp.761527

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VL - Vol.15

SP - 27

EP - 38

JO - Environmental health perspectives

JF - Environmental health perspectives

ER -

The role of biotransformation in chemical induced liver injury

Abstract

ASJC Scopus subject areas

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