The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field

Akitoshi Nakashima; Atsushi Furuta; Kiyotaka Yamada; Mihoko Yoshida-Kawaguchi; Akemi Yamaki-Ushijima; Ippei Yasuda; Masami Ito; Satoshi Yamashita; Sayaka Tsuda; Satoshi Yoneda; Shibin Cheng; Surendra Sharma; Tomoko Shima

doi:10.3390/biology12030373

The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field

Akitoshi Nakashima, Atsushi Furuta, Kiyotaka Yamada, Mihoko Yoshida-Kawaguchi, Akemi Yamaki-Ushijima, Ippei Yasuda, Masami Ito, Satoshi Yamashita, Sayaka Tsuda, Satoshi Yoneda, Shibin Cheng, Surendra Sharma, Tomoko Shima

Research output: Contribution to journal › Review article › peer-review

Abstract

Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this process has been shown to work in energy production, as well as in the reduction of excessive proteins, damaged organelles, and membrane trafficking. It contributes to many human diseases, such as neurodegenerative diseases, carcinogenesis, diabetes mellitus, development, longevity, and reproduction. In this review, we provide important information for interpreting results related to autophagic experiments and present the role of autophagy in this field.

Original language	English (US)
Article number	373
Journal	Biology
Volume	12
Issue number	3
DOIs	https://doi.org/10.3390/biology12030373
State	Published - Mar 2023
Externally published	Yes

Keywords

ER stress
LC3
NBR1
TFEB
autophagy
autophagy flux
decidualization
oxidative stress
p62
syncytiotrophoblasts

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

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10.3390/biology12030373

Cite this

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title = "The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field",

abstract = "Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this process has been shown to work in energy production, as well as in the reduction of excessive proteins, damaged organelles, and membrane trafficking. It contributes to many human diseases, such as neurodegenerative diseases, carcinogenesis, diabetes mellitus, development, longevity, and reproduction. In this review, we provide important information for interpreting results related to autophagic experiments and present the role of autophagy in this field.",

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month = mar,

doi = "10.3390/biology12030373",

language = "English (US)",

volume = "12",

journal = "Biology",

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T2 - For Beginners to Experts in This Field

AU - Nakashima, Akitoshi

AU - Furuta, Atsushi

AU - Yamada, Kiyotaka

AU - Yoshida-Kawaguchi, Mihoko

AU - Yamaki-Ushijima, Akemi

AU - Yasuda, Ippei

AU - Ito, Masami

AU - Yamashita, Satoshi

AU - Tsuda, Sayaka

AU - Yoneda, Satoshi

AU - Cheng, Shibin

AU - Sharma, Surendra

AU - Shima, Tomoko

PY - 2023/3

Y1 - 2023/3

N2 - Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this process has been shown to work in energy production, as well as in the reduction of excessive proteins, damaged organelles, and membrane trafficking. It contributes to many human diseases, such as neurodegenerative diseases, carcinogenesis, diabetes mellitus, development, longevity, and reproduction. In this review, we provide important information for interpreting results related to autophagic experiments and present the role of autophagy in this field.

AB - Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this process has been shown to work in energy production, as well as in the reduction of excessive proteins, damaged organelles, and membrane trafficking. It contributes to many human diseases, such as neurodegenerative diseases, carcinogenesis, diabetes mellitus, development, longevity, and reproduction. In this review, we provide important information for interpreting results related to autophagic experiments and present the role of autophagy in this field.

KW - ER stress

KW - LC3

KW - NBR1

KW - TFEB

KW - autophagy

KW - autophagy flux

KW - decidualization

KW - oxidative stress

KW - p62

KW - syncytiotrophoblasts

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DO - 10.3390/biology12030373

M3 - Review article

AN - SCOPUS:85152425137

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VL - 12

JO - Biology

JF - Biology

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ER -

The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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