The relation of plasmacytoid dendritic cells (pDCs) and regulatory t-cells (Tregs) with HPV persistence in HIV-Infected and HIV-Uninfected women

Howard D. Strickler; Jeffrey Martinson; Seema Desai; Xianhong Xie; Robert D. Burk; Kathryn Anastos; L. Stewart Massad; Howard Minkoff; Xiaonan Xue; Gypsyamber D'Souza; Alexandra M. Levine; Christine Colie; D. Heather Watts; Joel M. Palefsky; Alan Landay

doi:10.1089/vim.2013.0097

The relation of plasmacytoid dendritic cells (pDCs) and regulatory t-cells (Tregs) with HPV persistence in HIV-Infected and HIV-Uninfected women

Howard D. Strickler, Jeffrey Martinson, Seema Desai, Xianhong Xie, Robert D. Burk, Kathryn Anastos, L. Stewart Massad, Howard Minkoff, Xiaonan Xue, Gypsyamber D'Souza, Alexandra M. Levine, Christine Colie, D. Heather Watts, Joel M. Palefsky, Alan Landay

Research output: Contribution to journal › Article › peer-review

Abstract

Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.

Original language	English (US)
Pages (from-to)	20-25
Number of pages	6
Journal	Viral Immunology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1089/vim.2013.0097
State	Published - Feb 1 2014
Externally published	Yes

ASJC Scopus subject areas

Immunology
Molecular Medicine
Virology

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10.1089/vim.2013.0097

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Strickler, H. D., Martinson, J., Desai, S., Xie, X., Burk, R. D., Anastos, K., Massad, L. S., Minkoff, H., Xue, X., D'Souza, G., Levine, A. M., Colie, C., Watts, D. H., Palefsky, J. M., & Landay, A. (2014). The relation of plasmacytoid dendritic cells (pDCs) and regulatory t-cells (Tregs) with HPV persistence in HIV-Infected and HIV-Uninfected women. Viral Immunology, 27(1), 20-25. https://doi.org/10.1089/vim.2013.0097

Strickler, HD, Martinson, J, Desai, S, Xie, X, Burk, RD, Anastos, K, Massad, LS, Minkoff, H, Xue, X, D'Souza, G, Levine, AM, Colie, C, Watts, DH, Palefsky, JM & Landay, A 2014, 'The relation of plasmacytoid dendritic cells (pDCs) and regulatory t-cells (Tregs) with HPV persistence in HIV-Infected and HIV-Uninfected women', Viral Immunology, vol. 27, no. 1, pp. 20-25. https://doi.org/10.1089/vim.2013.0097

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abstract = "Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.",

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AU - Burk, Robert D.

AU - Anastos, Kathryn

AU - Massad, L. Stewart

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AU - D'Souza, Gypsyamber

AU - Levine, Alexandra M.

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AB - Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.

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The relation of plasmacytoid dendritic cells (pDCs) and regulatory t-cells (Tregs) with HPV persistence in HIV-Infected and HIV-Uninfected women

Abstract

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