TY - JOUR
T1 - The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites
AU - Prudente, Sabrina
AU - Chandalia, Manisha
AU - Morini, Eleonora
AU - Baratta, Roberto
AU - Dallapiccola, Bruno
AU - Abate, Nicola
AU - Fzrittitta, Lucia
AU - Trischitta, Vincenzo
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2007/1
Y1 - 2007/1
N2 - This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m2) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI ≥40 kg/m2), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 (KK), K121/Q121 (KQ), and Q121/Q121 (QQ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m2, respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m2 in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m2 vs. 25.7 ± 4.4 kg/m2; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.
AB - This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m2) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI ≥40 kg/m2), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 (KK), K121/Q121 (KQ), and Q121/Q121 (QQ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m2, respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m2 in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m2 vs. 25.7 ± 4.4 kg/m2; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.
KW - BMI
KW - Genetic susceptibility
UR - http://www.scopus.com/inward/record.url?scp=33846881568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846881568&partnerID=8YFLogxK
U2 - 10.1038/oby.2007.636
DO - 10.1038/oby.2007.636
M3 - Article
C2 - 17228024
AN - SCOPUS:33846881568
SN - 1930-7381
VL - 15
SP - 1
EP - 4
JO - Obesity
JF - Obesity
IS - 1
ER -