TY - JOUR
T1 - The prevention and treatment of breast cancer- related lymphedema
T2 - A review
AU - McEvoy, Maureen P.
AU - Gomberawalla, Ameer
AU - Smith, Mark
AU - Boccardo, Francesco M.
AU - Holmes, Dennis
AU - Djohan, Risal
AU - Thiruchelvam, Paul
AU - Klimberg, Suzanne
AU - Dietz, Jill
AU - Feldman, Sheldon
N1 - Publisher Copyright:
Copyright © 2022 McEvoy, Gomberawalla, Smith, Boccardo, Holmes, Djohan, Thiruchelvam, Klimberg, Dietz and Feldman.
PY - 2022/12/6
Y1 - 2022/12/6
N2 - Background: Breast cancer- related lymphedema (BCRL) affects about 3 to 5 million patients worldwide, with about 20,000 per year in the United States. As breast cancer mortality is declining due to improved diagnostics and treatments, the long-term effects of treatment for BCRL need to be addressed. Methods: The American Society of Breast Surgeons Lymphatic Surgery Working Group conducted a large review of the literature in order to develop guidelines on BCRL prevention and treatment. This was a comprehensive but not systematic review of the literature. This was inclusive of recent randomized controlled trials, meta-analyses, and reviews evaluating the prevention and treatment of BCRL. There were 25 randomized clinical trials, 13 systemic reviews and meta-analyses, and 87 observational studies included. Results: The findings of our review are detailed in the paper, with each guideline being analyzed with the most recent data that the group found evidence of to suggest these recommendations. Conclusions: Prevention and treatment of BCRL involve a multidisciplinary team. Early detection, before clinically apparent, is crucial to prevent irreversible lymphedema. Awareness of risk factors and appropriate practice adjustments to reduce the risk aids are crucial to decrease the progression of lymphedema. The treatment can be costly, time- consuming, and not always effective, and therefore, the overall goal should be prevention.
AB - Background: Breast cancer- related lymphedema (BCRL) affects about 3 to 5 million patients worldwide, with about 20,000 per year in the United States. As breast cancer mortality is declining due to improved diagnostics and treatments, the long-term effects of treatment for BCRL need to be addressed. Methods: The American Society of Breast Surgeons Lymphatic Surgery Working Group conducted a large review of the literature in order to develop guidelines on BCRL prevention and treatment. This was a comprehensive but not systematic review of the literature. This was inclusive of recent randomized controlled trials, meta-analyses, and reviews evaluating the prevention and treatment of BCRL. There were 25 randomized clinical trials, 13 systemic reviews and meta-analyses, and 87 observational studies included. Results: The findings of our review are detailed in the paper, with each guideline being analyzed with the most recent data that the group found evidence of to suggest these recommendations. Conclusions: Prevention and treatment of BCRL involve a multidisciplinary team. Early detection, before clinically apparent, is crucial to prevent irreversible lymphedema. Awareness of risk factors and appropriate practice adjustments to reduce the risk aids are crucial to decrease the progression of lymphedema. The treatment can be costly, time- consuming, and not always effective, and therefore, the overall goal should be prevention.
KW - LyMPHA
KW - axillary reverse mapping
KW - axillary surgery
KW - breast cancer
KW - breast cancer related lymphedema
KW - lymphedema
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U2 - 10.3389/fonc.2022.1062472
DO - 10.3389/fonc.2022.1062472
M3 - Review article
AN - SCOPUS:85144382590
SN - 2234-943X
VL - 12
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 1062472
ER -