The potential of tissue engineering in orthopedics

William J. Landis, Robin Jacquet, Jennifer Hillyer, Jean Zhang, Lorraine Siperko, Susan Chubinskaya, Shinichi Asamura, Noritaka Isogai

Research output: Contribution to journalArticlepeer-review


This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The cell-polymer constructs are vascularized by the host mice, form new bone, cartilage, and tendon with characteristic gene expression and protein synthesis and secretion, and maintain the shape of human phalanges with joints. The study demonstrates critical progress in the design and fabrication of bone, cartilage, and tendon by tissue engineering and the potential of this field for human clinical orthopedic applications.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalOrthopedic Clinics of North America
Issue number1
StatePublished - Jan 2005
Externally publishedYes

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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