The P55 protein affected by v-mos expression is vimentin

B. Singh, R. Goldman, L. Hutton, N. K. Herzog, R. B. Arlinghaus

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Rabbit antiserum prepared against a cyclic 19-amino-acid peptide predicted from the sequence of the viral mos gene (v-mos) of Moloney murine sarcoma virus not only recognized v-mos gene products but also specifically detected a 55,000-M(r) polypeptide expressed in a variety of cells that grow on solid surfaces. This normal cellular protein, previously shown to be reduced in amount in cells expressing the v-mos gene, was found to be the intermediate filament structural protein, vimentin. This conclusion was reached by comparing relative mobilities in denaturing gels, isoelectric points, immunoreactivities, location in the cell, and peptide maps.

Original languageEnglish (US)
Pages (from-to)3625-3629
Number of pages5
JournalJournal of virology
Issue number11
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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