The 'normal' brain. 'Abnormal' ubiquitinilated deposits highlight an age-related protein change

M. A. Pappolla, R. Omar, B. Saran

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Known morphologic changes that characterize 'normal' brain senescence are insufficient to explain the widespread, age-related decline of psychomotor functions. We report that the heavily ubiquitinilated depostis can be consistently detected by immunohistochemistry in the normal senescent brain. Immunostaining of hippocampal sections from aged brains with an anti-ubiquitin antibody was unrelated to neurofibrillary degeneration or senile plaque formation. In contrast, ubiquitin deposits were not detectable in brain sections from neurologically and neuropathologically normal young individuals who had died of nonneurological causes. This finding shows an unrecognized protein change in the normal aged brain.

Original languageEnglish (US)
Pages (from-to)585-591
Number of pages7
JournalAmerican Journal of Pathology
Issue number4
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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