The middle perforated substance of the diencephalon

Mohammadali M. Shoja, R. Shane Tubbs, Ghaffar Shokouhi, Marios Loukas, Kamyar Ghabili, W. Jerry Oakes

Research output: Contribution to journalArticlepeer-review


The diencephalon, upper brain stem and other basal brain structures are supplied chiefly by penetrating branches of the cerebral arteries. We examined the retrochiasmatic space between the superior border of the pons and posterior edge of the optic chiasm in six randomly selected adult fresh brain specimens. Lateral or anterolateral to the mamillary bodies, two small quadrangular spaces (2.5 × 3.5 mm) were found that were limited laterally by the junction of the optic tract and crus cerebri. These spaces were pierced on each side by 1 to 5 small penetrating branches (premamillary arterial complex) of the posterior communicating artery. A single, large and obliquely oriented penetrating branch of the posterior communicating artery (the so-called premamillary, thalamotuberal or mamillothalamic artery) was found to pierce this area in all specimens. Based on our findings, the above-mentioned vessels of this perforating substance supply the floor of third ventricle, hypothalamus and ventral thalamic nuclei. Hence, special attentions should be made during surgery in this area such as third ventriculostomy for hydrocephalus.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalItalian Journal of Anatomy and Embryology
Issue number2
StatePublished - Apr 2008
Externally publishedYes


  • Lateral perforating substance
  • Posterior communicating artery

ASJC Scopus subject areas

  • Anatomy
  • Embryology


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